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Factory Supply High Quality Evodiamine Powder

Active Pharmaceutical Ingredients

Factory Supply High Quality Evodiamine Powder

Product Name: Evodiamine

Specifications: 98%

Appearance: Light yellow fine Powder

CAS NO.: 518-17-2

Test Method: HPLC

Extraction Process: Extracted from Evodia Fructus

Sample: Free Sample

Stock: In Stock

Shelf Life: 2Years

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    Product Introduction

    Evodiamine is a naturally occurring indole alkaloid and the main biologically active component of the traditional Chinese medicine Evodiamine. It has pharmacological activities such as increasing blood pressure, anti-tumor, protecting the heart, losing weight, anti-inflammatory, analgesic, and anti-Alzheimer's disease. As a new natural anti-cancer drug, evodiamine can inhibit the proliferation of various tumor cells, including cervical cancer, colon cancer, lung cancer, melanoma Chemicalbook tumors, T lymphocyte-like leukemia, prostate cancer and breast cancer. . It also has other biological activities, such as regulating body temperature, resisting hypoxia, dermatological applications, bronchoconstriction and hormone secretion regulation. In addition, evodiamine has good binding ability to a variety of proteins, so it can exert a variety of biological activities as a multi-target compound.

    Evodiamine is a tryptamine indole alkaloid, yellow flake crystal or crystalline powder. Melting point: 278℃, specific optical rotation [α]D20+352° (acetone). Soluble in acetone, slightly soluble in chloroform, insoluble in water, benzene and petroleum ether. When exposed to concentrated sulfuric acid or concentrated hydrochloric acid, it appears orange-red, turns to reddish-brown when placed, dilutes with water and turns to blue, and produces a dirty blue precipitate after alkalization. It is extracted and isolated from the fruits of Evodia Evodia. Has the effect of increasing blood pressure.

    Function

    Evodiamine has stomachic, analgesic, anti-retching and anti-abdominal effects; it has a diuretic effect; it has a strong inhibitory effect on Escherichia coli; it has a significant insecticidal effect on Ascaris suum; it also has uterine contraction and blood pressure increasing effects. It is also effective in treating Alzheimer's disease and stroke.
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    Product Feature

    1. Anti-tumor activity
    Evodiamine can inhibit the proliferation of a variety of tumor cells, including cervical cancer, colon cancer, lung cancer, melanoma, T lymphocyte-like leukemia, prostate cancer, and breast cancer.

    2. Anti-Alzheimer's disease Alzheimer's disease (AD), also known as Alzheimer's disease, is a progressive and irreversible brain disease, mainly caused by the degeneration of nerve synapses and nerve damage. Cell death results in impairment of the patient's cognition, memory and behavior.

    3. Effects on the endocrine system Evodiamine can reduce the activity of intracellular cyclic adenosine monophosphate (cAMP)-related pathways, inhibit the activity of 3β-hydroxysteroid dehydrogenase (3β-HSD) and other Chemicalbook steroid hormone production-related enzymes, and reduce It also affects signal transduction and RNA activation protein (StAR) expression, and directly acts on rat adrenocortical fasciculus cells to inhibit corticosterone secretion.

    4. Weight loss and hypoglycemic effects
    After 13 weeks of evodiamine intervention in rats, the body weight and Lee's index of obese rats were reduced, the visceral fat weight and visceral fat weight index of obese rats were reduced, and the serum total cholesterol and triglyceride contents of obese rats were reduced. Evodiamine can reverse vascular hypertrophy complicated by obesity.

    5. Anti-inflammatory and analgesic effects
    Evodiamine can dose-dependently inhibit the expression of cyclooxygenase (COX-2) and nitric oxide synthase (iNOS), and reduce the release of prostaglandin (E2). Evodiamine exerts analgesic effects by desensitizing sensory nerves.

    6. Effects on the cardiovascular system
    Effect on the heart. Low concentrations of evodiamine can accelerate the spontaneous rhythm of guinea pig heart tissue and increase contractility in vitro.
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    Product Data Sheets

    Analysis Description Results
    Appearance Light yellow fine powder Conforms
    Identification IR spectrum Conforms
    Solubility(1g in 10mlMEOH) SOLUBLE Conforms
    Melting Point 265℃~275℃ 268℃~269℃
    Moisture NMT2.0% 0.10%
    Lead NMT3ppm Conforms
    As NMT3ppm Conforms
    Cd NMT0.3ppm Conforms
    Hg NMT0.2ppm Conforms
    Assay(HPLC) 98.0%min 99.90%

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