Active Pharmaceutical Ingredients
Product Introduction
Citrus flavonoids are mainly found in the outer skin of citrus fruits (including the outer pericarp and capsule). Citrus is often used as a traditional Chinese medicine and has a history of thousands of years in China. Research on the biological activities and anti-cancer activities of citrus flavonoids has been carried out in depth. The flavonoids can be roughly traced according to their flavonoid structure naming: flavonoids, such as naringenin, hesperetin, etc.; polymethylone flavonoids, such as Sichuan orange tangerine.
Among them, hesperidin auxiliary drugs improve patients' vascular diseases; hesperidin has antioxidant and analgesic effects, and when used in combination with diomin, both in vivo and in vitro research results show obvious protective effects; combined with grapefruit peel, It has cholesterol-lowering and anti-cancer effects; clinical studies have shown that it can reduce menopause in women.
Among them, hesperidin auxiliary drugs improve patients' vascular diseases; hesperidin has antioxidant and analgesic effects, and when used in combination with diomin, both in vivo and in vitro research results show obvious protective effects; combined with grapefruit peel, It has cholesterol-lowering and anti-cancer effects; clinical studies have shown that it can reduce menopause in women.
Product Data Sheets
| Analysis | Description | Result |
| Total flavonoid content, (in rutin)% | ≥40.0 | Complies |
| Shape and properties | Light brown yellow powder | Complies |
| Smell | Unique smell, bitter taste | Complies |
| Shuifen,% | ≤5.0 | Complies |
| Ash content,% | ≤5.0 | Complies |
| Particle size (80-mesh screen) | 95% through 80 mesh | Complies |
| Heavy metal ppm | ≤10.0 | Complies |
| Lead ppm | ≤1.0 | Complies |
| Arsenic ppm | ≤1.0 | Complies |
| Mercury ppm | ≤0.3 | Complies |
| Total number of colonies, CFU / g | ≤1000 | Complies |
| Mold and yeasts, and CFU / g | ≤100 | Complies |
| Colibacillus | Colibacillus | |
| Salmonella phylum | Salmonella phylum | |
Product Function
1.Biological activities such as antioxidant, anti-inflammatory, lipid-lowering, anti-cancer, bacteriostatic, hepatoprotection and neuroprotection
For example, naringenin can significantly inhibit the transcription of IL-6, inhibit the infiltration of macrophages in adipose tissue, and help to improve the hepatic steatosis induced by free fatty acids; hesperidin induced the apoptosis of lung cancer cells by downregulating the expression of PCNA protein, β -catenin and c-myc. Moreover, clinical trials have demonstrated that intake of citrus flavonoids improves metabolic syndrome and cardiovascular disease etc.
2.Improve the stability, solubility, and sustained-release properties.
After encapsulation, orange flavonoids can improve stability, solubility and sustained release, so they have a positive impact on a variety of physiological functions. For example, encapsulation can enhance the permeability of the active ingredients, improve the retention time, make them accumulate in the tumor site and reduce toxicity, so as to play an anti-cancer effect.
3. It has a relatively potent antibacterial activity
We have shown that the nanosphere formed by encapsulating naringin in the PLA-glycolic acid polymer has strong antibacterial activity. When the mass concentration was 0.2 mg/mL, the killing rate of E. coli and S. aureus reached 99.9% within 24 h, and inhibited the survival rate of tumor cells. Table 1 summarizes the effects of the major citrus flavonoid components on physiological function.
For example, naringenin can significantly inhibit the transcription of IL-6, inhibit the infiltration of macrophages in adipose tissue, and help to improve the hepatic steatosis induced by free fatty acids; hesperidin induced the apoptosis of lung cancer cells by downregulating the expression of PCNA protein, β -catenin and c-myc. Moreover, clinical trials have demonstrated that intake of citrus flavonoids improves metabolic syndrome and cardiovascular disease etc.
2.Improve the stability, solubility, and sustained-release properties.
After encapsulation, orange flavonoids can improve stability, solubility and sustained release, so they have a positive impact on a variety of physiological functions. For example, encapsulation can enhance the permeability of the active ingredients, improve the retention time, make them accumulate in the tumor site and reduce toxicity, so as to play an anti-cancer effect.
3. It has a relatively potent antibacterial activity
We have shown that the nanosphere formed by encapsulating naringin in the PLA-glycolic acid polymer has strong antibacterial activity. When the mass concentration was 0.2 mg/mL, the killing rate of E. coli and S. aureus reached 99.9% within 24 h, and inhibited the survival rate of tumor cells. Table 1 summarizes the effects of the major citrus flavonoid components on physiological function.
Product Application
1.Health care products
The human body cannot synthesize flavonoids, mainly relying on a certain amount of flavonoids from vegetables, fruits, grains and other foods. Flavonoids are rapidly metabolized in the body, so they need continuous supplementation. The amount of flavonoids is similar to the amount of vitamin C. There are now a large number of flavonoids on the market extracted from plants rich in flavonoids as dietary supplements to make a variety of health foods or foods. At present, the main plants used to extract flavonoids are citrus peel, ginkgo biloba, hawthorn, tea and so on.
2.Medicine field
Traditional Chinese medicine believes that tangerine peel has the effect of removing cold and resolving phlegm, relieving cough and producing fluid, regulating qi and strengthening stomach, and dispersing and warming temperature. Modern medical research has shown that orange peel extract has antioxidant, anti-aging, anti-tumor, anti-allergy, anti-virus, anti-inflammatory, prevent cardiovascular disease and other activities. In fact, the main roles are flavonoids. Citrus flavonoids is a pure natural green compound extracted from citrus peel, which potentially has many inestimable pharmacological value to our human beings.
3.API
Flavonoids are both pharmacological factors and an important class of nutritional factors, and are a class of newly discovered nutrients.
4.Cosmetics
Using citrus peel from new technology, a new yellow powder is a pure natural high-tech product, and has applied for patent authorization and realized industrialization; tyrosinase inhibition test and cell culture melanin production test show that the product has significant whitening effect, better than arbutin.
The human body cannot synthesize flavonoids, mainly relying on a certain amount of flavonoids from vegetables, fruits, grains and other foods. Flavonoids are rapidly metabolized in the body, so they need continuous supplementation. The amount of flavonoids is similar to the amount of vitamin C. There are now a large number of flavonoids on the market extracted from plants rich in flavonoids as dietary supplements to make a variety of health foods or foods. At present, the main plants used to extract flavonoids are citrus peel, ginkgo biloba, hawthorn, tea and so on.
2.Medicine field
Traditional Chinese medicine believes that tangerine peel has the effect of removing cold and resolving phlegm, relieving cough and producing fluid, regulating qi and strengthening stomach, and dispersing and warming temperature. Modern medical research has shown that orange peel extract has antioxidant, anti-aging, anti-tumor, anti-allergy, anti-virus, anti-inflammatory, prevent cardiovascular disease and other activities. In fact, the main roles are flavonoids. Citrus flavonoids is a pure natural green compound extracted from citrus peel, which potentially has many inestimable pharmacological value to our human beings.
3.API
Flavonoids are both pharmacological factors and an important class of nutritional factors, and are a class of newly discovered nutrients.
4.Cosmetics
Using citrus peel from new technology, a new yellow powder is a pure natural high-tech product, and has applied for patent authorization and realized industrialization; tyrosinase inhibition test and cell culture melanin production test show that the product has significant whitening effect, better than arbutin.
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Product Data Sheets
| Analysis | Description | Result |
| Total flavonoid content, (in rutin)% | ≥40.0 | Complies |
| Shape and properties | Light brown yellow powder | Complies |
| Smell | Unique smell, bitter taste | Complies |
| Shuifen,% | ≤5.0 | Complies |
| Ash content,% | ≤5.0 | Complies |
| Particle size (80-mesh screen) | 95% through 80 mesh | Complies |
| Heavy metal ppm | ≤10.0 | Complies |
| Lead ppm | ≤1.0 | Complies |
| Arsenic ppm | ≤1.0 | Complies |
| Mercury ppm | ≤0.3 | Complies |
| Total number of colonies, CFU / g | ≤1000 | Complies |
| Mold and yeasts, and CFU / g | ≤100 | Complies |
| Colibacillus | Colibacillus | |
| Salmonella phylum | Salmonella phylum | |