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FDA Approved Chinese leading manufacturer Hirudin Most Active And Most Studied Active Ingredients Extracted From Leeches And Their Salivary Glands

Active Pharmaceutical Ingredients

FDA Approved Chinese leading manufacturer Hirudin Most Active And Most Studied Active Ingredients Extracted From Leeches And Their Salivary Glands

Product Name: Hirudin

Chemical name: HIRUDIN (54-65) (DESULFATED)

CAS number: 113274-56-9

Molecular formula: C66H93N13O25

Molecular weight: 1468.52

Melting point: 340-345°C

Boiling point: 1913.6±65.0 °C(Predicted)

Density: 1.384±0.06 g/cm3(Predicted)

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    Product Introduction

    Hirudin is one of the most active and most studied active ingredients extracted from leeches and their salivary glands. It is a small molecule polypeptide composed of 65-66 amino acids. Leeches are rich in hirudin, which has a strong inhibitory effect on thrombin and is the strongest natural specific inhibitor of thrombin discovered so far. Hirudin has a strong inhibitory effect on coagulation and anti-thrombosis, and has broad application prospects in clinical treatment and prevention of various thrombosis.

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    Product Function

    Anticoagulant effect
    Hirudin has a highly specific and efficient inhibitory effect on thrombin. It can directly inhibit thrombin and hinder the proteolytic function of thrombin, so it has an anticoagulant effect. Compared with heparin, hirudin requires less dosage, does not cause bleeding, and does not rely on endogenous cofactors.

    Anti-thrombotic effect
    Improve microcirculation and promote metabolism. It can absorb the hematoma of acute cerebral hemorrhage, reduce the inflammatory reaction and edema around the brain tissue, alleviate the increase in intracranial pressure, improve local circulation, and is conducive to the recovery of neurological function; it is also effective for experimental hematoma in the ear. Promote absorption.

    Improve cholesterol and triglyceride effects
    Leeches have a significant lowering effect on cholesterol and triglycerides in experimental hyperlipidemia. Hirudin has an inhibitory effect on tumor cells and has a certain inhibitory effect on the growth of liver cancer. Because leeches have a high anticoagulant effect, they are beneficial for anti-cancer drugs and immune-active cells to penetrate into cancer tissue and kill cancer cells.

    Anti-myocardial ischemia and arrhythmia effects
    Its aqueous extract has obvious antagonistic effects on acute myocardial ischemia and arrhythmia; intraperitoneal injection of hirudin can increase nutritional blood flow. Intravenous injection of leech liquid can promote and reduce atrial fibrillation and peripheral inflammatory reactions, and experiments on subcutaneous hematoma have similar results.

    Effect on diabetes and its complications
    Insulin resistance is common in patients with type I diabetes, accounting for almost 90%. Hirudin can be used as an insulin sensitizer, which can enhance the body's sensitivity to its own insulin, resurrecting its own insulin and giving full play to its role, lowering blood sugar. Diabetes will destroy all blood vessel walls, produce inflammatory reactions, form thrombus, and lead to Necrosis of eyes, kidneys, lower limbs, etc. Hirudin can reduce the inflammatory response of blood vessel walls and prevent thrombosis.

    Inhibit proliferative vitreoretinopathy
    0.1 mL (10 units) of hirudin was injected into the vitreous cavity of rabbits, and 0.1 mL of normal saline was injected into the control group. The contents of laminin and type IV collagen in the vitreous cavity were measured using radioimmunoassay. The results showed that the hirudin group was more The content in the control group decreased significantly, and hirudin had a certain inhibitory effect on traumatic proliferative vitreoretinopathy.
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    Product Application

    Cardiovascular system diseases and tumors are two major diseases that mainly harm human health. Drugs to prevent and treat these two major diseases are the focus of new drug development. The efficacy of leeches in breaking blood, removing blood stasis, stimulating menstruation, and eliminating diseases has been proven by thousands of years of traditional Chinese medicine practice in my country. The role of recombinant hirudin in anticoagulation and thrombolysis and in conjunction with tumor chemotherapy and radiotherapy has also been proven by foreign clinical trials. prove. The requirements for injections are relatively high. It is estimated that economic benefits of at least hundreds of millions of yuan can be obtained by replacing leeches with recombinant hirudin peptide drugs or as an additive ingredient in Chinese patent medicines. With the expansion of clinical trials, it will be able to be used to prevent and treat more diseases, and its development prospects are very broad.

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