Active Pharmaceutical Ingredients
Product Introduction
Oleanolic acid is a pentacyclic triterpenoid compound extracted from the fruit of Swertia or ligustris of Gentiaceae. It exists in a variety of plants in the form of free bodies and glycosomes. Oleanolic acid is widely found in plants, with a general content of 0.2% to 2% [1]. The content of cucurbitaceae is 1.5% ~ 2%, and the content of Ligustrum fruit is 0.6% ~ 0.7%. Oleanolic acid is a white acicular crystal (ethanol), odorless and tasteless. Unstable to acids and bases. Melting point 308 ~ 310℃, [α]20D+73.3° (c=0.15, chloroform), insoluble in water, soluble in methanol, ethanol, ether, acetone and chloroform。
Product Data Sheets
| Test Item | Standard | Result | Individual judgment |
| Appearance | Light brown crystalline powder; Odorless and tasteless | Conformance to Requirements | Qualified |
| Loss on drying | ≤8% | 7.50% | Qualified |
| Residue | ≤7% | 5.70% | Qualified |
| Assay | ≥4.0% | 4.20% | Qualified |
| Conclusion | The above items have been inspected and the results meet the requirements of the standard | ||
Product Function
1.Alleviating liver injury: Oleanolic acid is a pentacyclic triterpenoid compound, which has obvious protective effect on acute and chronic liver injury caused by carbon tetrachloride in rats. After treatment, enlarged mitochondria and enlarged rough endoplasmic reticulum were restored. The ballooning degeneration, necrosis and inflammatory reaction of hepatocytes in acute and chronic liver injury can be significantly reduced. The accumulation of triglycerides in the liver decreased and the amount of glycogen increased.
2. Decrease the activity of serum alanine aminotransferase: Oleanolic acid can significantly decrease the enzyme in acute and chronic hepatitis and liver cirrhosis animals.
3. Decreased serum R-globulin and was consistent with the reduction of liver-related inflammatory response seen in histological observations.
4. Promote the regeneration of hepatocytes: Oleanolic acid can promote the number of mitotic phases in the residual liver of rats to increase significantly, and the regeneration degree is higher than that of the control group, suggesting that it has the role of promoting cell regeneration.
5. Reduce the level of cooline in the brain homogenate of rats with liver cirrhosis: Because the level of cooline in the brain homogenate decreased significantly, it can inhibit the production of false neurotransmitters, so it is conducive to the prevention and treatment of hepatic encephalopathy.
6. Inhibition of liver fibrosis: After oleanolic acid treatment of liver fibrosis in rats, liver fibrosis is serious and significantly reduced, liver collagen content is reduced, suggesting the role of prevention and treatment of liver cirrhosis.
7. Oleanolic acid can significantly inhibit mononuclear phagocyte system, macrophage phagocytosis and experimental arthritis in mice, but it can affect the humoral immune function of opposite sex and antigen-binding cells. Enhance immunity and inhibit the growth of S180 tumor strain.
8. It has a protective effect on chromosome damage, a preventive effect on experimental atherosclerosis, and can also correct protein metabolism disorders
Product Application
Oleanolic acid is a broad spectrum antibacterial drug, which is used in the treatment of bronchitis, pneumonia, acute tonsillitis, periodontitis, bacillary dysentery, acute gastroenteritis and urinary system infection. In addition, it is also used to treat acute hepatitis
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Product Data Sheets
| Test Item | Standard | Result | Individual judgment |
| Appearance | Light brown crystalline powder; Odorless and tasteless | Conformance to Requirements | Qualified |
| Loss on drying | ≤8% | 7.50% | Qualified |
| Residue | ≤7% | 5.70% | Qualified |
| Assay | ≥4.0% | 4.20% | Qualified |
| Conclusion | The above items have been inspected and the results meet the requirements of the standard | ||