Khoom Taw Qhia
- Spermidine, tseem hu ua spermidine trihydrochloride, yog polyamine. Nws yog dav faib nyob rau hauv cov kab mob nyob thiab yog biosynthesized los ntawm putrescine (butanediamine) thiab adenosylmethionine. Spermidine tuaj yeem inhibit neuronal synthase, khi thiab precipitate DNA; Nws tseem tuaj yeem siv los ua kom huv DNA-binding proteins thiab txhawb nqa T4 polynucleotide kinase kev ua haujlwm. Thaum lub Cuaj Hlis 1, 2013, cov kws tshawb fawb los ntawm lub teb chaws Yelemees thiab Austria koom ua ke tshawb fawb thiab hais tias spermidine tuaj yeem tiv thaiv qhov pib ntawm Alzheimer's disease.
Txheej Txheem Ua Haujlwm
Khoom muaj nuj nqi
- Spermidine tuaj yeem ncua kev laus ntawm cov protein. Vim tias cov proteins ntawm qhov hnyav molecular sib txawv tuaj yeem ua lub luag haujlwm sib txawv hauv cov txheej txheem senescence, qee qhov loj molecular hnyav proteins tuaj yeem ua lub luag haujlwm tseem ceeb hauv kev tswj cov txheej txheem senescence ntawm nplooj. Thaum cov proteins no pib degrade, senescence yog inevitable, thiab nws yog ib qho nyuaj rau tswj lub degradation ntawm cov proteins. Nws tuaj yeem ncua kev laus. Qhov laj thawj yog vim li cas spermidine tuaj yeem ncua kev laus tuaj yeem txhawb nqa cov synthesis ntawm cov proteins lossis tiv thaiv lawv cov degradation.
Khoom siv
- Spermidine yog ib qho hnyav molecular aliphatic carbide uas muaj peb pawg amine thiab yog ib qho ntawm cov polyamines ntuj muaj nyob rau hauv tag nrho cov kab mob. Nws yog ib qho tseem ceeb raw khoom rau tshuaj synthesis thiab yog dav siv nyob rau hauv synthesis ntawm kws tshuaj intermediates.Spermidine koom nrog ntau cov txheej txheem lom neeg hauv cov kab mob, xws li tswj kev loj hlob ntawm tes, cell senescence, kev loj hlob ntawm lub cev, kev tiv thaiv kab mob, mob qog noj ntshav thiab lwm yam txheej txheem physiological thiab pathological. Cov kev tshawb fawb tsis ntev los no tau pom tias spermidine plays lub luag haujlwm tseem ceeb hauv cov txheej txheem xws li synaptic plasticity, oxidative stress, thiab autophagy hauv lub paj hlwb.