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What is Eucommia Chlorogenic Acid?

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What is Eucommia Chlorogenic Acid?

2024-09-07 10:52:05

The extract is extracted from the dry bark and leaves of the eucommia ulmoides (EucommiauimoidesOliv). The active ingredients are mainly lignin, cycloether mushrooms, phenylpropanoids and other mushroom compounds, as well as polysaccharides, flavonoids, phenols, etc. Chlorogenic acid is a phenylpropanoid compound produced by the mang Chemicalbook oxalate pathway during aerobic respiration. Chlorogenic acid is an important bioactive substance, which has the functions of antibacterial, antiviral, increasing white blood cells, liver and gallbladder protecting, anti-tumor, lowering blood pressure-lowering, lowering blood lipid, removing free radicals and excitatory central nervous system. It is widely used, mainly used in medicine, daily chemicals and food and other industries.


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Health Benefits of Eucommia Chlorogenic Acid

Antioxidative and free radical removal effect than ascorbic acid, caffeic acid and tocopherol (vitamin E), it can effectively remove DPPH radicals, hydroxyl radicals and superoxide anionic radicals, and can also inhibit the oxidation of low-density lipoprotein. Chlorogenic acid plays an important role in effectively removing free radicals in the body, maintaining the normal structure and function of the body cells, and preventing and delaying the occurrence of tumor mutation and aging. 


2. Antibacterial and antiviral effects chlorogenic acid and isochlorogenic acid have significant inhibitory and killing effects on a variety of pathogenic bacteria, such as Staphylococcus aureus, hemolytic streptococcus, dysentery coccal, typhoid bacterium, pneumococcus, and their antibacterial mechanism is related to non-competitive inhibition of arylaminoacetyltransferase (NAT) in bacteria.


Chlorogenic acid has obvious effect on acute throat inflammation and skin disease, and is used in the treatment of acute bacterial infection. It has been reported in the literature that chlorogenic acid has the effects of antiviral, hemostasis, increasing white blood cells, shortening hemagglutination and bleeding time.


3. Anti-mutation and anti-tumor effect chlorogenic acid has a strong ability to suppress mutations, can inhibit the mutations caused by aflatoxin B and sub-digestive reaction, and can effectively reduce the bone marrow red blood cell mutation caused by γ -ray; chlorogenic acid can achieve cancer prevention and anticancer effect by reducing the utilization rate of carcinogens and its transport in the liver. Chlorogenic acid significantly inhibits Chemicalbook for colorectal cancer, liver cancer and laryngeal cancer, and is considered as an effective chemical protective agent for cancer.


As a free radical scavenger and antioxidant, chlorogenic acid has been proved in a large number of trials. This biological activity of chlorogenic acid can have a protective effect on the cardiovascular system. By removing free radicals, chlorogenic acid can protect vascular endothelial cells against lipid peroxidation, and then play a role in the prevention and treatment of atherosclerosis, thromboembolic diseases and hypertension.


5. Cholesterol lowering effect After euzhong alcohol extract infusion of rats, the serum total cholesterol was significantly lower than that of the control group, proving that Eucommia ulmoides inhibited cholesterol absorption.


6. Bone cell proliferation of Eucommia ulmoides and aqueous extract and UMR106 osteogenic cells cultured in vitro, the results showed that aqueous extract in 0.4 g / liter culture 48 hours has the strongest promoting cell proliferation, the ethyl acetate extract and n-butanol extract has certain effect on cell proliferation, and the remaining water layer still retained with the raw water layer similar to promote cell proliferation.


7. Immunomodulatory extract preparation of Eucommia ulmoides leaves can increase the RNA and protein synthesis of the spleen weight and spleen tissue damaged by cyclophosphamide, improve the activity of natural killer cells in the blood, accelerate the proliferation of spleen lymphocytes, and have no obvious effect on the spleen antibody forming cells in normal mice.


8. Sex hormone and sex hormone-like action eucommia ulmoides extract can increase the weight of prostate, ovary, testis and levator muscle in animals.


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Sources of Eucommia Chlorogenic Acid

It is the dry bark, branches and leaves of euulmoides.Born in the low valley of 300~500m, low slope. Distribution in Shaanxi, Gansu, Jiangsu, Zhejiang, Henan, Sichuan, Guizhou and Yunnan. It is now widely cultivated throughout China.


Eucommia Chlorogenic Acid COSMETIC 

The euulmoides leaf extract is added to the cosmetics.


[Raw material compatibility] The mass ratio range of eucommia leaf extract in cosmetics is 0.3~1, preferably 0.4~0.8, and most preferably 0.5. Cosmetics can be selected from beauty cream, evening cream, eye cream, facial cleanser, skin toner Chemicalbook, massage cream, wrinkle removal cream and facial mask.


[Product application] Eucommia ulmoides leaf extract can be added to a variety of forms of cosmetics for skin care, wrinkle removal and anti-aging.


[Product characteristics] Eucommia ulmoides leaf extract can be well integrated with various cosmetics, with simple process and low cost; cosmetics are safe and effective.


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Research on Eucommia Chlorogenic Acid
Objective The extraction technology of chlorogenic acid from Eucommia ulmoides leaf was studied with Ethanol as solvent. Methods Main factors influencing the extraction of chlorogenic acid from the leaves of Eucommia ulmoides were studied by single factor experiments, and then the optimized conditions for the extraction of chlorogenic acid were studied by orthogonal test.Results Optimized conditions were obtained as follows: Ethanol concentration 60%;extraction temperature 60℃; extraction time 2.5h; material to solvent 1:12. Conclusion The extraction ratio of chlorogenic acid was 2.434% in the optimized conditions.

Conclusion 
A protocol for extracting chlorogenic acid from Eucommia ulmoides leaf was optimized by orthogonal test on the base of noticeable factors test. The preventing effect of extract of Eucommia ulmoides leaf on mice suffered from high lipid serum was evaluated. High lipid serum was induced by gavaging fat emulsion to mice everyday. The TC, TG, LDL-C and HDL-C level in the serum of different animal groups were monitored. The result showed that the optimum process was to extract the chlorogenicacid at 90 ℃ with 70% ethanol for 2 h, with solid-liquid ratio 1:16, and the extract rate was able to reach to 4%. The extract was efficient in defending high lipid serum.


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