What is hesperidin used for?

1.What is Hesperidin？

Hesperidin is a bioflavonoid abundantly found in citrus fruits, offering numerous health benefits such as antioxidant, antibacterial, antimicrobial, anti-inflammatory, and anticarcinogenic properties. The food industry, particularly juice production, utilizes large quantities of citrus fruits, generating substantial by-products like peels, seeds, and cell membrane residues, which are rich sources of hesperidin. Consequently, extracting hesperidin from these by-products has garnered significant scientific attention due to its potential as a natural antioxidant. This review discusses the methods for extracting and quantifying hesperidin in citrus fruits and their by-products, along with its stability and biological activities.

Keywords: Hesperidin

Hesperidin (3,5,7-trihydroxyflavanone 7-rhamnoglucoside, hesperetin-7-O-rutino- side) belongs to flavanone compounds, one of the flavonoids subclasses. It has been recently extensively evaluated for its health-promoting and pharmacological effects and is used in a treatment of type 2 diabetes, cancer and cardiovascular diseases, neurological and psychiatric disorders, as well as a radioprotector . Administrations of hesperidin can also benefit a variety of cutaneous function in both normal and diseases skin .

2.What Are the Benefits of Hesperidin?

High Blood Pressure

A clinical trial involving 159 participants aged 18 to 65 with prehypertension or stage 1 hypertension found that consuming orange juice containing hesperidin for 12 weeks led to a consistent reduction in systolic blood pressure and pulse pressure, an indicator of arterial stiffness. The results were dose-dependent, meaning that higher hesperidin powder consumption led to lower blood pressure. However, the study's findings may not be representative of the general population.

Stroke

Recombinant tissue plasminogen activator (rt-PA) is used to treat ischemic stroke but can cause adverse effects such as symptomatic intracerebral hemorrhage (SIH). A study of 341 people with ischemic stroke found that adding hesperidin to rt-PA therapy reduced the risk of SIH and improved recovery within one day of treatment.

Heart Attack

A clinical trial with 75 participants aged 40 to 65 who had experienced a heart attack found that daily hesperidin supplements reduced inflammation within four weeks and improved fat, sugar metabolism, and high-density lipoprotein cholesterol levels.

Hemorrhoids

A clinical trial of 134 individuals aged 18 to 75 with acute hemorrhoidal disease found that a mixture of flavonoids, including diosmin, troxerutin, and hesperidin, reduced anal pain and bleeding within 12 days and improved swelling and blood clots compared to a placebo group. However, the effect of hesperidin alone on acute hemorrhoidal disease remains unclear.

Diabetes

A clinical trial of 64 individuals aged 30 to 65 with a history of diabetes for at least three years found that hesperidin supplements improved blood sugar control after six weeks and reduced inflammation and DNA damage. More research is needed to confirm these results.

Liver Disease

Two clinical trials found that hesperidin, alone or in combination with flaxseed supplementation, improved sugar and fat metabolism, reduced inflammatory markers, and lowered inflammation in participants with metabolic dysfunction-associated steatotic liver disease (MASLD) or nonalcoholic fatty liver disease. However, further studies are needed to determine the long-term outcomes of hesperidin supplementation in people with MASLD.

Cognitive Health

Two clinical studies found that consuming citrus juice containing hesperidin increased blood flow to the brain and improved cognitive function in healthy young and older adults. However, more human clinical studies with larger sample sizes are needed to understand how hesperidin enhances cognitive function.

3.Dosage: How Much Hesperidin Should I Take?

Dosage Recommendations for Hesperidin:

Before starting any supplement, it's crucial to consult with a healthcare provider to determine the appropriate dosage that meets your individual needs. The dosage of hesperidin can vary depending on the specific condition being treated and the form in which it is consumed.

In clinical trials, different doses of hesperidin have been used for various conditions. For prehypertension or stage 1 hypertension, 345 mg to 600 mg of hesperidin per day, naturally present in or enriched orange juice, have been administered for 12 weeks. For improving treatment outcomes of ischemic stroke and managing adverse effects of rt-PA therapy, a dose of 4 mg per kilogram of body weight (up to a maximum of 400 mg) has been taken orally during rt-PA treatment.

In cases of heart attack, a daily dose of 600 mg of pure hesperidin taken orally with breakfast for four weeks has been used. For venous ulcers, a combination of diosmin and hesperidin (450 mg diosmin and 50 mg hesperidin) taken orally twice daily for 90 days has been prescribed. For hemorrhoidal disease, a specific powder formula containing diosmin, troxerutin, hesperidin, and vitamin C has been diluted in water and taken orally in varying doses over a period of 12 days, followed by a tablet containing these flavonoids taken daily for a month.

For type 2 diabetes, a daily dose of 500 mg of hesperidin taken orally for six weeks has been used. In studies addressing metabolic syndrome-associated fatty liver disease (MASLD, formerly NAFLD), a total daily dose of 1 g of hesperidin (two 500 mg capsules) taken orally for 12 weeks has been administered.

Regarding cognitive function, different studies have used citrus juice containing varying amounts of hesperidin. One study used 500 mL of citrus juice containing 42.15 mg of hesperidin to improve blood flow to the brain, while another study gave participants orange juice containing either 275 mg or 32 mg of hesperidin daily for eight weeks.

Overall, most clinical trials have used oral supplement forms of hesperidin ranging from 300 mg to 600 mg per day. When consumed as citrus juice, the typical dosage is approximately 500 mL or two full glasses of juice. It's important to note that these dosages are based on clinical trials and should not be taken as medical advice. Always consult with a healthcare provider to determine the appropriate dosage for your specific needs.

The specific dosage should be determined according to the advice of medical professionals.

4.Where can I buy hesperidin powder?

To purchase hesperidin, please contact Sost biotech Factory.

Reference:

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