Ibicuruzwa
Kumenyekanisha ibicuruzwa
Citrus flavonoide iboneka cyane muruhu rwinyuma rwimbuto za citrusi (harimo pericarp yo hanze na capsule). Citrus ikunze gukoreshwa nkubuvuzi gakondo bwabashinwa kandi ifite amateka yimyaka ibihumbi mubushinwa. Ubushakashatsi bwibikorwa byibinyabuzima nibikorwa byo kurwanya kanseri ya citrus flavonoide byakozwe mubwimbitse. Flavonoide irashobora gukurikiranwa hafi ukurikije imiterere ya flavonoide yitiriwe: flavonoide, nka naringenin, hesperetin, nibindi.; polymethylone flavonoide, nka tangeri ya Sichuan orange.
Muri byo, imiti ifasha hesperidin itezimbere indwara zifata abarwayi; hesperidin ifite antioxydeant na analgesic, kandi iyo ikoreshejwe ifatanije na diomin, haba muri vivo ndetse no mubisubizo byubushakashatsi bwa vitro byerekana ingaruka zigaragara zo kubarinda; ifatanije nigishishwa cyinzabibu, Ifite cholesterol igabanya n'ingaruka zo kurwanya kanseri; ubushakashatsi ku mavuriro bwerekanye ko bushobora kugabanya gucura ku bagore.
Muri byo, imiti ifasha hesperidin itezimbere indwara zifata abarwayi; hesperidin ifite antioxydeant na analgesic, kandi iyo ikoreshejwe ifatanije na diomin, haba muri vivo ndetse no mubisubizo byubushakashatsi bwa vitro byerekana ingaruka zigaragara zo kubarinda; ifatanije nigishishwa cyinzabibu, Ifite cholesterol igabanya n'ingaruka zo kurwanya kanseri; ubushakashatsi ku mavuriro bwerekanye ko bushobora kugabanya gucura ku bagore.
Imikorere y'ibicuruzwa
1.Ibikorwa bya biologiya nka antioxydeant, anti-inflammatory, kugabanya lipide, kurwanya kanseri, bacteriostatike, hepatoprotection na neuroprotection
Kurugero, naringenin irashobora kubuza cyane iyandikwa rya IL-6, ikabuza kwinjira muri macrophage mumyanya ya adipose, kandi igafasha kunoza imiterere ya hepatike iterwa na acide yubusa; hesperidin yateje apoptose ya selile kanseri y'ibihaha mu kugabanya imvugo ya poroteyine ya PCNA, β -catenin na c-myc. Byongeye kandi, ibizamini byo kwa muganga byagaragaje ko gufata citrus flavonoide biteza syndrome de metabolike n'indwara z'umutima n'imitsi n'ibindi.
2.Gutezimbere ituze, kwikemurira ibibazo, hamwe no gukomeza-kurekura ibintu.
Nyuma ya ensapsulation, orange flavonoide irashobora kunoza ituze, gukomera no kurekurwa kurambye, bityo bigira ingaruka nziza kumikorere itandukanye ya physiologique. Kurugero, encapsulation irashobora kongera ubushobozi bwibintu bikora, kunoza igihe cyo kugumana, bigatuma byegeranya ahantu h’ibibyimba no kugabanya uburozi, kugirango bigire ingaruka zo kurwanya kanseri.
3. Ifite ibikorwa bya antibacterial ikomeye cyane
Twerekanye ko nanosikori ikozwe na enapsuline naringin muri polymer ya PLA-glycolike ifite ibikorwa bikomeye bya antibacterial. Iyo ubwinshi bwa misa bwari 0.2 mg / mL, ubwicanyi bwa E. coli na S. aureus bwageze kuri 99.9% mu masaha ya 24 h, kandi bibuza kubaho ingirabuzimafatizo. Imbonerahamwe 1 yerekana muri make ingaruka zingenzi za citrus flavonoid kumikorere ya physiologique.
Kurugero, naringenin irashobora kubuza cyane iyandikwa rya IL-6, ikabuza kwinjira muri macrophage mumyanya ya adipose, kandi igafasha kunoza imiterere ya hepatike iterwa na acide yubusa; hesperidin yateje apoptose ya selile kanseri y'ibihaha mu kugabanya imvugo ya poroteyine ya PCNA, β -catenin na c-myc. Byongeye kandi, ibizamini byo kwa muganga byagaragaje ko gufata citrus flavonoide biteza syndrome de metabolike n'indwara z'umutima n'imitsi n'ibindi.
2.Gutezimbere ituze, kwikemurira ibibazo, hamwe no gukomeza-kurekura ibintu.
Nyuma ya ensapsulation, orange flavonoide irashobora kunoza ituze, gukomera no kurekurwa kurambye, bityo bigira ingaruka nziza kumikorere itandukanye ya physiologique. Kurugero, encapsulation irashobora kongera ubushobozi bwibintu bikora, kunoza igihe cyo kugumana, bigatuma byegeranya ahantu h’ibibyimba no kugabanya uburozi, kugirango bigire ingaruka zo kurwanya kanseri.
3. Ifite ibikorwa bya antibacterial ikomeye cyane
Twerekanye ko nanosikori ikozwe na enapsuline naringin muri polymer ya PLA-glycolike ifite ibikorwa bikomeye bya antibacterial. Iyo ubwinshi bwa misa bwari 0.2 mg / mL, ubwicanyi bwa E. coli na S. aureus bwageze kuri 99.9% mu masaha ya 24 h, kandi bibuza kubaho ingirabuzimafatizo. Imbonerahamwe 1 yerekana muri make ingaruka zingenzi za citrus flavonoid kumikorere ya physiologique.
Gusaba ibicuruzwa
1.Ibicuruzwa byita ku buzima
Umubiri wumuntu ntushobora guhuza flavonoide, cyane cyane ushingiye kumubare runaka wa flavonoide ukomoka ku mboga, imbuto, ibinyampeke nibindi biribwa. Flavonoide ihindagurika vuba mumubiri, bityo ikenera inyongera zihoraho. Ingano ya flavonoide isa nubunini bwa vitamine C. Ubu hari isoko ryinshi rya flavonoide ku isoko ryakuwe mu bimera bikungahaye kuri flavonoide nk'inyongeramusaruro yo gukora ibiryo bitandukanye byubuzima cyangwa ibiryo. Kugeza ubu, ibihingwa nyamukuru bikoreshwa mu gukuramo flavonoide ni igishishwa cya citrusi, ginkgo biloba, hawthorn, icyayi nibindi.
2.Umurima wubuvuzi
Ubuvuzi gakondo bw'Abashinwa bwizera ko igishishwa cya tangerine gifite ingaruka zo gukuraho ubukonje no gukemura ibicurane, kugabanya inkorora no gutanga amazi, kugenga qi no gukomeza igifu, no gukwirakwiza n'ubushyuhe. Ubushakashatsi bwubuvuzi bugezweho bwerekanye ko ibishishwa bya orange bifite antioxydants, birwanya gusaza, birwanya ibibyimba, anti-allergie, anti-virusi, anti-inflammatory, birinda indwara zifata umutima nimiyoboro nibindi bikorwa. Mubyukuri, inshingano nyamukuru ni flavonoide. Citrus flavonoide nicyatsi kibisi kibisi cyakuwe mubishishwa bya citrus, gishobora kuba gifite agaciro gakomeye ka farumasi kubantu bacu.
3.API
Flavonoide ni ibintu bya farumasi nicyiciro cyingenzi cyimirire, kandi ni icyiciro cyintungamubiri zavumbuwe.
4.Isiga
Ukoresheje ibishishwa bya citrus biva mu ikoranabuhanga rishya, ifu nshya yumuhondo nigicuruzwa cyiza gisanzwe cyubuhanga buhanitse, kandi cyasabye uruhushya rwa patenti kandi rushyira mubikorwa inganda; ikizamini cyo kubuza tyrosinase n'umuco w'akagari melanin ikizamini cyerekana ko ibicuruzwa bifite ingaruka zikomeye zo kwera, kuruta arbutine.
Umubiri wumuntu ntushobora guhuza flavonoide, cyane cyane ushingiye kumubare runaka wa flavonoide ukomoka ku mboga, imbuto, ibinyampeke nibindi biribwa. Flavonoide ihindagurika vuba mumubiri, bityo ikenera inyongera zihoraho. Ingano ya flavonoide isa nubunini bwa vitamine C. Ubu hari isoko ryinshi rya flavonoide ku isoko ryakuwe mu bimera bikungahaye kuri flavonoide nk'inyongeramusaruro yo gukora ibiryo bitandukanye byubuzima cyangwa ibiryo. Kugeza ubu, ibihingwa nyamukuru bikoreshwa mu gukuramo flavonoide ni igishishwa cya citrusi, ginkgo biloba, hawthorn, icyayi nibindi.
2.Umurima wubuvuzi
Ubuvuzi gakondo bw'Abashinwa bwizera ko igishishwa cya tangerine gifite ingaruka zo gukuraho ubukonje no gukemura ibicurane, kugabanya inkorora no gutanga amazi, kugenga qi no gukomeza igifu, no gukwirakwiza n'ubushyuhe. Ubushakashatsi bwubuvuzi bugezweho bwerekanye ko ibishishwa bya orange bifite antioxydants, birwanya gusaza, birwanya ibibyimba, anti-allergie, anti-virusi, anti-inflammatory, birinda indwara zifata umutima nimiyoboro nibindi bikorwa. Mubyukuri, inshingano nyamukuru ni flavonoide. Citrus flavonoide nicyatsi kibisi kibisi cyakuwe mubishishwa bya citrus, gishobora kuba gifite agaciro gakomeye ka farumasi kubantu bacu.
3.API
Flavonoide ni ibintu bya farumasi nicyiciro cyingenzi cyimirire, kandi ni icyiciro cyintungamubiri zavumbuwe.
4.Isiga
Ukoresheje ibishishwa bya citrus biva mu ikoranabuhanga rishya, ifu nshya yumuhondo nigicuruzwa cyiza gisanzwe cyubuhanga buhanitse, kandi cyasabye uruhushya rwa patenti kandi rushyira mubikorwa inganda; ikizamini cyo kubuza tyrosinase n'umuco w'akagari melanin ikizamini cyerekana ko ibicuruzwa bifite ingaruka zikomeye zo kwera, kuruta arbutine.
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Urupapuro rwibicuruzwa
| Isesengura | Ibisobanuro | Igisubizo |
| Ibirimo flavonoide yose, (muri rutin)% | ≥40.0 | Bikubiyemo |
| Imiterere n'imiterere | Ifu yumuhondo yijimye | Bikubiyemo |
| Impumuro | Impumuro idasanzwe, uburyohe bukaze | Bikubiyemo |
| Shuifen,% | ≤5.0 | Bikubiyemo |
| Ibirimo ivu,% | ≤5.0 | Bikubiyemo |
| Ingano y'ibice (ecran ya 80-mesh) | 95% kugeza kuri 80 mesh | Bikubiyemo |
| Icyuma kiremereye ppm | ≤10.0 | Bikubiyemo |
| Kurongora ppm | ≤1.0 | Bikubiyemo |
| Arsenic ppm | ≤1.0 | Bikubiyemo |
| Mercury ppm | ≤0.3 | Bikubiyemo |
| Umubare rusange wabakoloni, CFU / g | 0001000 | Bikubiyemo |
| Imisemburo n'imisemburo, na CFU / g | ≤100 | Bikubiyemo |
| Colibacillus | Colibacillus | |
| Salmonella phylum | Salmonella phylum | |