Active Pharmaceutical Ingredients
Product Introduction
Oleanolic acid is a pentacyclic triterpenoid compound isolated and extracted from the whole herb of Swertia spp. or the fruit of Ligustrum lucidum of the Gentianaceae family. It exists in a variety of plants in the form of free bodies and glycosides. It has become a commonly used liver-protecting drug in clinical practice. It has a significant protective effect on acute and chronic liver damage in rats caused by carbon tetrachloride, can reduce elevated ALT and AST, reduce inflammation, necrosis and interstitial inflammatory reactions, prevent fibrosis formation, promote liver cell regeneration, and accelerate the recovery of necrotic tissue. Electron microscopy shows that after treatment with oleanolic acid, enlarged mitochondria and rough endoplasmic reticulum are restored. Its succinate can reduce the activity of mouse liver microsomal cytochrome P450 enzymes. In addition, oleanolic acid has the effects of correcting protein metabolism disorders, anti-inflammatory, cardiotonic, diuretic, increasing white blood cells, lowering blood sugar, promoting immune function, and inhibiting the growth of S-180 tumor strains.
Product Function
1. Oleanolic acid has anti-inflammatory, sedative, cardiotonic, diuretic, lipid-lowering, blood sugar-lowering, liver-protecting, enzyme-lowering, immune-enhancing and S180 tumor cell growth-inhibiting effects. It is an effective ingredient for the development of drugs for the treatment of liver disease and blood sugar reduction.
2. Oleanolic acid has a protective effect on chromosome damage and a preventive effect on experimental atherosclerosis. It is clinically used to treat infectious acute icteric hepatitis and chronic viral hepatitis, and has a significant effect of reducing alanine aminotransferase and jaundice.
3. Oleanolic acid has the effect of inhibiting liver fibrosis. In rats with liver fibrosis treated with oleanolic acid, liver fibrosis was severe and significantly reduced, and the content of liver collagen was reduced, indicating that it has the effect of preventing and treating liver cirrhosis.
4. Reduce the level of tyrosine in brain homogenate of rats with liver cirrhosis: Since the level of tyrosine in brain homogenate is significantly reduced, it can inhibit the generation of pseudo-neurotransmitters, so it is beneficial to the prevention and treatment of hepatic encephalopathy.
5. Oleanolic acid capsules are over-the-counter drugs for liver disease auxiliary medications, used for the auxiliary treatment of acute and chronic hepatitis. It has a certain protective effect on liver damage, can reduce elevated serum alanine aminotransferase, promote liver cell regeneration, and accelerate the repair of necrotic tissue.
Product Application
Used for food industry, health care products and pharmaceuticals.
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