Active Pharmaceutical Ingredients
Product Introduction
Andrographolide andrographolide is a kind of organic matter, molecular formula C20H30O5, white square prism or sheet crystallization. The main effective ingredient of natural plant lotus piercing, has the effect of removing heat and detoxification, anti-inflammatory and analgesic, and has a special effect on bacterial and viral upper respiratory tract infection and dysentery, which is known as a natural antibiotic drug. This product is a diterpenoid lactone compound, are insoluble in water, usually only orally.
Product Data Sheets
| Analysis | Description | Result |
| Appearance | Colorless crystalline powder; Odorless | Complies |
| Water-Solubility | This product is dissolved in boiling ethanol, slightly dissolved in methanol or ethanol, very slightly dissolved in chloroform, and almost insoluble in water. | Complies |
| Melting point | 224～230℃ | Complies |
| Other lactone | In the test chromatography, no other spots except the main spot | Complies |
| Ignition residue | No more than 0.1% | 0.04% |
| Loss on drying | No more than 1.0% | 0.30% |
| Assaying | Lactone containing C20H30O5 should be 95.0%~101.0% | 98.28% |
Product Function
1. Role of antipathogenic microorganisms
Animal experiments showed that both andrographolide and neandroholide could inhibit and delay the temperature increase caused by dicoccus pneumoniae or streptococcus, but andrographolide had a stronger effect than neandrographolide.
In vitro experiments show that andrographia has some anti-HIV effect.
2. Decrease of heat
Andrographolide has different degrees of antipyretic effect on the fever caused by rabbit endotoxin fever, pneumococcus or hemolytic streptococcus bacteria. The antipyretic effect of methyl, B, C, and butyrin on fever in rabbits or hot rats caused by 2,4-dinitrophenol was successively weakened.
3. Anti-inflammatory action
Andrographia, B, C, and butytin all have different anti-inflammatory effects. 1g / kg perfusion can inhibit the increase of skin or abdominal capillary permeability caused by xylene or acetic acid, reduce the acute exudate amount of soybean oil caused by serol oil in Selye granulation sac, but have no obvious effect on granulation tissue hyperplasia. It could inhibit the development of foot swelling in egg white rats, but the effect disappeared after adrenal removal. Butytin has the strongest anti-inflammatory effect, followed by propylene, methyl and ethylene.
Andrographia lotus has an obvious effect of stopping pregnancy. Oral lotus can make mice contraception, pregnant rabbits abortion. The intraperitoneal injection of water decoction had a significant stopping effect on the implantation, early pregnancy, middle pregnancy and late pregnancy. Dramuscular injection, subcutaneous injection, perfusion, intraperitoneal injection, intravenous injection and intrauterine injection can produce anti-early pregnancy effect, among which intraperitoneal, intravenous and intrauterine injection has the best effect. Intrauterine injection, the dosage is small, the effect is good. If exogenous progesterone or luteinizing hormone release, hormone (LH-RH) and lotus perforator injection at the same time, it can prevent abortion, which suggests that lotus perforator may have the effect against progesterone in the body, thus causing abortion. It has been suggested that andrographia inhibited the growth of placental villous trophoblast cells cultured in vitro. Studies have shown that some semi-synthetic derivatives also have different degrees of early pregnancy effect, dehydration hydrographolide derivatives-wear-4 for mice and rats have good early pregnancy effect, is worthy of further study of a new contraceptive drug, the drug has significant influence on the placental trophoblast leaf cells, can make the placental villus atrophy, cell number, cells and langham cells disappear, interstitial edema bleeding.
4. Effect on the immune function of the body
There are reports that andrographia may have a role in some aspects of cellular immunity. Its decoction in vitro can improve the ability of human leukocytes to phagocytosis Staphylococcus aureus, and oral lotus can enhance the skin delay hypersensitivity caused by old tuberculin. New inflammation (containing ester and ketone) can improve the level of lysozyme in mice and enhance the phagocytic capacity of peritoneal macrophages and neutrophils. Continuous administration of andrographolide sulphation to rabbits or mice can significantly increase the phagocytic ability of peripheral blood phagocytes to pneumococcus or Staphylococcus aureus. Andrographolin injection and Xiyanping injection can also enhance the phagocyte function. Dehydrated Andrographolide succinate also inhibited delayed hypersensitivity due to 2,4-dinitrochlorobenzene in mice.
5. Antifertility Action
6. Libile protects liver effect
Andrographia has a beneficial bile effect on rats and can increase rat liver.
Product Application
1. Medicine
Andrographolide is the main raw material of Andrographolide. Andrographis paniculata is a traditional Chinese herbal medicine in our country. It tastes bitter and cold. It has the function of clearing heat and detoxification, reducing inflammation and eliminating swelling. Andrographis paniculata likes high temperature, moist and sunny environment, and the southeast coastal areas such as Guangdong and Fujian are the main producing areas of Andrographis paniculata in China.
2. Health care products
A variety of products with andrographolide as the main component have appeared on the market, such as andrographolide tablets, andrographolide dropping pills, andrographolide mask, etc. Among them, the injection made with andrographolide as the active ingredient is the important product, including Chuanhuning needle, Yanhuning needle, Lianbizhi needle and so on.
3. Cosmetics
The invention relates to a synthesis for skin cell proliferation containing andrographolide extract or andrographolide or its salt, and a synthesis for skin condition improvement of said synthesis. The synthesis of the invention causes stem cells and skin cells to secrete growth factors. factor), which promotes cell proliferation. The synthetic substance of the invention can improve skin wrinkles, inhibit skin aging, improve skin elasticity, improve skin regeneration ability, improve healing wounds and scars, etc., and has the effect of improving skin condition.
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Product Data Sheets
| Analysis | Description | Result |
| Appearance | Colorless crystalline powder; Odorless | Complies |
| Water-Solubility | This product is dissolved in boiling ethanol, slightly dissolved in methanol or ethanol, very slightly dissolved in chloroform, and almost insoluble in water. | Complies |
| Melting point | 224～230℃ | Complies |
| Other lactone | In the test chromatography, no other spots except the main spot | Complies |
| Ignition residue | No more than 0.1% | 0.04% |
| Loss on drying | No more than 1.0% | 0.30% |
| Assaying | Lactone containing C20H30O5 should be 95.0%~101.0% | 98.28% |