Product Introduction
Cordycepin, also known as cordyceps sinensis, cordycepin, cordycepin, alias 3′ -deoxyadenosine, chemical formula C10H13N5O3, is the first nucleoside antibiotic isolated from fungi.
In the 1950s, Wild cordyceps militaris was found around the Changbai Mountain in Jilin province, Studies proved that its ingredients are far better than wild cordyceps, So it named the north cordyceps sinensis; In 1951, German scientists Cunningham et al discovered for the first time the core component of cordyceps militaris "cordycepin", It was found to have antibacterial, anti-inflammatory, antiviral, anti-tumor and immune regulation and other pharmacological activities; For the following decades, The academic circle has carried out a large number of research on cordycepin; In 1997, Cordycepin has been used in phase III clinical trials, For the treatment of patients with acute anterior B and pre-T lymphocytic leukemia; In 2017, Professor Wang Chengshu of the Chinese Academy of Sciences published the latest research results on cordycepin in Cell Cell Chemical Biology online: this study fully analyzed the biosynthesis mechanism of cordycepin in cordyceps militaris (Cordyceps militaris), And the first discovery that Cordyceps militaris can synthesize the anticancer drug ——— inastine, The compound was used to protect the structural stability of the synthesized cordycepin.
The results showed that cordycepin has protective,anti-trihigh, anti-tumor, neuroprotective, anti-inflammatory , anti-oxidation and immunomodulation. Therefore, cordycepin has attracted much attention in the fields of anti-aging, health care, new drug research and development.
In the 1950s, Wild cordyceps militaris was found around the Changbai Mountain in Jilin province, Studies proved that its ingredients are far better than wild cordyceps, So it named the north cordyceps sinensis; In 1951, German scientists Cunningham et al discovered for the first time the core component of cordyceps militaris "cordycepin", It was found to have antibacterial, anti-inflammatory, antiviral, anti-tumor and immune regulation and other pharmacological activities; For the following decades, The academic circle has carried out a large number of research on cordycepin; In 1997, Cordycepin has been used in phase III clinical trials, For the treatment of patients with acute anterior B and pre-T lymphocytic leukemia; In 2017, Professor Wang Chengshu of the Chinese Academy of Sciences published the latest research results on cordycepin in Cell Cell Chemical Biology online: this study fully analyzed the biosynthesis mechanism of cordycepin in cordyceps militaris (Cordyceps militaris), And the first discovery that Cordyceps militaris can synthesize the anticancer drug ——— inastine, The compound was used to protect the structural stability of the synthesized cordycepin.
The results showed that cordycepin has protective,anti-trihigh, anti-tumor, neuroprotective, anti-inflammatory , anti-oxidation and immunomodulation. Therefore, cordycepin has attracted much attention in the fields of anti-aging, health care, new drug research and development.
Product Function
1.Lung and kidney protection
According to traditional Chinese medicine, cordyceps into the lung and kidney can not only fill the lung Yin, but also tonify the kidney Yang. It is a kind of traditional Chinese medicine that can balance and regulate Yin and Yang at the same time.
2. Anti-three-high effect
Three high is the general name of high blood fat, hypertension and hyperglycemia. According to research, the aggregation of these three clinical diseases is not accidental, and the three pairs affect each other. Some studies have shown that cordycepin has a good effect on lowering blood lipid, which also affects fat genesis. In 2008, Zhao Haiyan et al. found that cordycepin could produce a certain protective effect on pancreatic cells under high sugar. In the treatment of early atherosclerosis, cordycepin inhibited the inflammatory response while protecting the integrity of the vascular endothelium.
3.Anti-tumor effect
The results suggest that cordycepin may inhibit the proliferation of cancer cells by regulating p85 / AKT or GSK 3 β -r. Kim et al. found that the fermented cordycepin mycial liquor was more effective in inhibiting melanoma. And further inhibiting the proliferation of melanoma by promoting Bax apoptotic protein expression in melanoma cells.
4. Neuroprotection and regulation
Cordycepin has the function of neuroprotection and regulation, and can effectively protect animal neurons. Jin et al found that cordycepin reduced the increase of ROS and Ca 2 + levels caused by glutamate, and its anti-apoptotic effect was partially dependent on the activation of adenosine A1 receptor, and the results indicated that cordycepin may be a potential therapeutic agent for neuronal diseases. Chen et al found that cordycepin has important neuroprotective effects in hypoxic or ischemic injury. During the electrophysiological mechanism of cordycepin protection from ischemia and hypoxic injury, it was found that cordycepin (80 μmol/L) can significantly delay the hypoxia-induced membrane depolarization, prolong the ability of spontaneous action potential (AP) distribution, and delay the occurrence of rapid depolarization.
Cardiovascular and cerebrovascular diseases have become one of the high incidence diseases in human beings, and most of the causes are related to the nervous system. Cerebral hemorrhage caused by neurological problems often occurs quickly, and life will be lost without timely treatment. Research and develop the neuroprotective and regulatory effects of cordycepin can prevent the occurrence of such diseases and reduce the morbidity.
5.Anti-inflammatory antibacterial effect
The antimicrobial activity and mechanism of action of cordycepin have been extensively studied. In 1951, after the researchers found that cordycepin had antibacterial effect, Cunningham et al first reported the inhibitory effect of cordycepin on bacteria. They applied cordycepin to 45 strains of Bacillus subtilis (Bacillussubtilis) and found that 43 of them their growth was inhibited by cordycepin. Li et al found that cordycepin inhibited the formation of colonies in the lungs of infected mice, and found that cordycepin enhanced the antibacterial activity of PA-824. The formation of a new compound with amide bond after connecting it with the structural amino group of cordycepin also has antibacterial effect
6. Immunomodulation and antioxidant effects
The pharmacological effects of cordycepin are extensive. In recent years, the research on its immune regulation and antioxidant is increasing, and the mechanism of action has been gradually clarified.
Cordycepin can effectively reduce intracellular malondialdehyde (MDA) content and intracellular reactive oxygen species (ROS) levels, and significantly increase superoxide dismutase (SOD) and glutathione peroxidase.
According to traditional Chinese medicine, cordyceps into the lung and kidney can not only fill the lung Yin, but also tonify the kidney Yang. It is a kind of traditional Chinese medicine that can balance and regulate Yin and Yang at the same time.
2. Anti-three-high effect
Three high is the general name of high blood fat, hypertension and hyperglycemia. According to research, the aggregation of these three clinical diseases is not accidental, and the three pairs affect each other. Some studies have shown that cordycepin has a good effect on lowering blood lipid, which also affects fat genesis. In 2008, Zhao Haiyan et al. found that cordycepin could produce a certain protective effect on pancreatic cells under high sugar. In the treatment of early atherosclerosis, cordycepin inhibited the inflammatory response while protecting the integrity of the vascular endothelium.
3.Anti-tumor effect
The results suggest that cordycepin may inhibit the proliferation of cancer cells by regulating p85 / AKT or GSK 3 β -r. Kim et al. found that the fermented cordycepin mycial liquor was more effective in inhibiting melanoma. And further inhibiting the proliferation of melanoma by promoting Bax apoptotic protein expression in melanoma cells.
4. Neuroprotection and regulation
Cordycepin has the function of neuroprotection and regulation, and can effectively protect animal neurons. Jin et al found that cordycepin reduced the increase of ROS and Ca 2 + levels caused by glutamate, and its anti-apoptotic effect was partially dependent on the activation of adenosine A1 receptor, and the results indicated that cordycepin may be a potential therapeutic agent for neuronal diseases. Chen et al found that cordycepin has important neuroprotective effects in hypoxic or ischemic injury. During the electrophysiological mechanism of cordycepin protection from ischemia and hypoxic injury, it was found that cordycepin (80 μmol/L) can significantly delay the hypoxia-induced membrane depolarization, prolong the ability of spontaneous action potential (AP) distribution, and delay the occurrence of rapid depolarization.
Cardiovascular and cerebrovascular diseases have become one of the high incidence diseases in human beings, and most of the causes are related to the nervous system. Cerebral hemorrhage caused by neurological problems often occurs quickly, and life will be lost without timely treatment. Research and develop the neuroprotective and regulatory effects of cordycepin can prevent the occurrence of such diseases and reduce the morbidity.
5.Anti-inflammatory antibacterial effect
The antimicrobial activity and mechanism of action of cordycepin have been extensively studied. In 1951, after the researchers found that cordycepin had antibacterial effect, Cunningham et al first reported the inhibitory effect of cordycepin on bacteria. They applied cordycepin to 45 strains of Bacillus subtilis (Bacillussubtilis) and found that 43 of them their growth was inhibited by cordycepin. Li et al found that cordycepin inhibited the formation of colonies in the lungs of infected mice, and found that cordycepin enhanced the antibacterial activity of PA-824. The formation of a new compound with amide bond after connecting it with the structural amino group of cordycepin also has antibacterial effect
6. Immunomodulation and antioxidant effects
The pharmacological effects of cordycepin are extensive. In recent years, the research on its immune regulation and antioxidant is increasing, and the mechanism of action has been gradually clarified.
Cordycepin can effectively reduce intracellular malondialdehyde (MDA) content and intracellular reactive oxygen species (ROS) levels, and significantly increase superoxide dismutase (SOD) and glutathione peroxidase.
Product Application
1.Application of cordycepin in the pharmaceutical industry
As early as 1997, cordycepin was used in phase I clinical trials, and cordycepin could be used as an immune enhancer and new functional materials for wound healing.
2.Application of cordycepin in the cosmetics industry
It has been reported that cordycepin has potential therapeutic effects in skin regulation, skin hypersensitivity and inflammation, in addition, cordycepin has anti-light, aging and anti-pigmentation activities.
3.Application of cordycepin in the functional food industry
Adding it to all kinds of food, beverage, wine, tea and candy to play its effect, which will become an important research direction for the food industry in the future.
4.Application of cordycepin in animal husbandry
The various biological activities of cordycepin are of great application value in animal husbandry. In addition, cordycepin can promote electrolyte leakage and accumulation of malondialdehyde on the ground of radish.
As early as 1997, cordycepin was used in phase I clinical trials, and cordycepin could be used as an immune enhancer and new functional materials for wound healing.
2.Application of cordycepin in the cosmetics industry
It has been reported that cordycepin has potential therapeutic effects in skin regulation, skin hypersensitivity and inflammation, in addition, cordycepin has anti-light, aging and anti-pigmentation activities.
3.Application of cordycepin in the functional food industry
Adding it to all kinds of food, beverage, wine, tea and candy to play its effect, which will become an important research direction for the food industry in the future.
4.Application of cordycepin in animal husbandry
The various biological activities of cordycepin are of great application value in animal husbandry. In addition, cordycepin can promote electrolyte leakage and accumulation of malondialdehyde on the ground of radish.
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Product Data Sheets
Analysis | Description | Testing method |
Appearance | Brown to yellowish brown powder | Conform |
Identity | HP-TLC; Botanical reference | Nasil |
Particle Size | 95% through 80 mesh | HPLC |
Flavor | Typical of cordyceps militaris extract, no off flavor | Conform |
Cordycepin | >1.0 % | HPLC |
Moisture | <7.0 % | GB 5009.3 |
Total Ash | <9.0 % | GB 5009.4 |
Arsenic | <1.0 mg/kg | BS EN ISO 17294-2/ICP-MS |
Lead | <1.0 mg/kg | BS EN ISO 17294-2/ICP-MS |
Mercury | <0.1 mg/kg | BS EN 13806/AAS |
Cadmium | <1.0 mg/kg | BS EN ISO 17294-2/ICP-MS |
Total Plate Count | <3,000 cfu/g | GB 4789.2 |
Mold | <100 cfu/g | GB 4789.15 |
Yeast | <100 cfu/g | GB 4789.15 |
Coliforms | <10 cfu/g | GB 4789.3 |
Salmonella | Negative/25g | GB 4789.4/ISO 6579-1 |
Staphylococcus | Negative/25g | GB 4789.10 |
E.coli | Negative/g | GB 4789.38/ISO 7251 |