Umhlinzeki Wesitolo Osezitolo WaseShayina I-Spermidine ISO Certified

Isingeniso Somkhiqizo

• I-Spermidine, eyaziwa nangokuthi i-spermidine trihydrochloride, iyi-polyamine. Isatshalaliswa kabanzi ezintweni eziphilayo futhi yenziwa nge-biosynthesized kusuka ku-purescine (butanediamine) kanye ne-adenosylmethionine. I-Spermidine ingavimbela i-neuronal synthase, ibophe futhi ifake i-DNA; ingasetshenziswa futhi ukuhlanza amaprotheni abopha i-DNA futhi ikhuthaze umsebenzi we-T4 polynucleotide kinase. Ngo-September 1, 2013, ososayensi baseJalimane nase-Austria benza ucwaningo ngokuhlanganyela futhi bathi i-spermidine ingase ivimbele ukuqala kwesifo i-Alzheimer's.
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Inqubo Ukuhamba komsebenzi

Umsebenzi Womkhiqizo

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• I-Spermidine ingabambezela ukuguga kwamaprotheni. Ngenxa yokuthi amaprotheni anesisindo samangqamuzana ahlukene angase adlale izindima ezihlukene enqubweni ye-senescence, amanye amaprotheni amakhulu esisindo samangqamuzana angase adlale indima ebalulekile ekulawuleni inqubo ye-senescence yamaqabunga. Uma la maprotheni eqala ukuwohloka, ukubukeka kwe-senescence akunakugwenywa, futhi kunzima ukulawula ukuwohloka kwalawa maprotheni. Kungabambezela inqubo yokuguga. Isizathu sokuthi kungani i-spermidine ingabambezela ukuguga kungase kube ukukhuthaza ukuhlanganiswa kwalawa maprotheni noma ukuvimbela ukuwohloka kwawo.

Isicelo somkhiqizo

• I-Spermidine iyisisindo esiphansi se-aliphatic carbide equkethe amaqembu amathathu e-amine futhi ingenye ye-polyamine yemvelo ekhona kuzo zonke izinto eziphilayo. Kuyimpahla ebalulekile yokwenziwa kwezidakamizwa futhi isetshenziswa kabanzi ekuhlanganiseni ama-intermediate emithi.

  
  

  I-Spermidine ihileleke ezinkambisweni eziningi zezinto eziphilayo eziphilayo, njengokulawula ukwanda kwamangqamuzana, i-cell senescence, ukuthuthukiswa kwezitho, ukungatheleleki, umdlavuza kanye nezinye izinqubo ze-physiological and pathological. Ucwaningo lwakamuva lubonise ukuthi i-spermidine idlala indima ebalulekile yokulawula ezinkambisweni ezifana ne-synaptic plasticity, i-oxidative stress, kanye ne-autophagy ohlelweni lwezinzwa.
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