Active Pharmaceutical Ingredients
what is Ashwagandha Root Extract Withanolides?
Ashwagandha extract Withanolides are active steroidal lactone compounds extracted from the roots of Ashwagandha (Withania somnifera), and are the core components responsible for the adaptogenic effects of this ancient medicinal plant.
Withanolides from Ashwagandha primarily consist of several structurally similar compounds, such as withanoside I, withanoside II, and withanoside VI. These active ingredients exert powerful physiological regulatory functions through synergistic effects. Xi'an Sost Biotech Co., Ltd. utilizes advanced supercritical CO2 extraction technology to ensure the extraction of high-purity, high-activity withanolides from Ashwagandha, with standardized content ranging from 1.5% to 12%, meeting the needs of different customers.
Withanolides from Ashwagandha primarily consist of several structurally similar compounds, such as withanoside I, withanoside II, and withanoside VI. These active ingredients exert powerful physiological regulatory functions through synergistic effects. Xi'an Sost Biotech Co., Ltd. utilizes advanced supercritical CO2 extraction technology to ensure the extraction of high-purity, high-activity withanolides from Ashwagandha, with standardized content ranging from 1.5% to 12%, meeting the needs of different customers.
COA
|
Analysis |
Specification |
Results |
|
|
Total Withanolides (On dry wt. basis) (HLPC) |
≥5.0% |
5.61% |
|
|
Identification |
Positive Reaction |
Complies |
|
|
Appearance |
Brown fine powder |
Complies |
|
|
Ash |
≤5.0% |
2.3% |
|
|
Moisture |
≤5.0% |
3.58% |
|
|
Heavy metals |
≤10ppm |
Complies |
|
|
Pb |
≤2.0ppm |
Complies |
|
|
As |
≤2.0ppm |
Complies |
|
|
Hg |
≤0.1ppm |
Complies |
|
|
Cd |
0.3ppm |
Complies |
|
|
Odor |
Characteristic |
Complies |
|
|
Particle size |
100%through 80 mesh |
Complies |
|
|
Bulk Density |
≥0.25 gm/ml |
0.54gm/ml |
|
|
Tapped Density |
≥0.30 gm/ml |
0.78gm/ml |
|
|
Microbioiogical ： |
|||
|
Total of bacteria |
≤10000cfu/g |
Complies |
|
|
Fungi |
≤100cfu/g |
Complies |
|
|
Salmgosella |
Negative |
Complies |
|
|
Coli |
Negative |
Complies |
|
The main effects of Withanolides (from Ashwagandha)
Stress Management and Cortisol Regulation: Clinical studies show that daily intake of 300-600mg of standardized ashwagandha extract (containing 5% withanolides) can significantly reduce serum cortisol levels by 27.9%, effectively alleviating chronic stress and anxiety symptoms.
Cognitive Function Enhancement: By promoting neuronal regeneration and synaptic plasticity, ashwagandha extract can improve attention, memory, and information processing speed. A double-blind controlled trial involving 50 adults showed that after 8 weeks of supplementation, participants' cognitive test scores improved by 18.7%.
Improved Sleep Quality: Ashwagandha extract powder regulates GABA receptor activity, extending deep sleep duration and reducing sleep latency. Studies show that insomniac patients who took 120mg of standardized extract nightly experienced a 72% improvement in their Pittsburgh Sleep Quality Index (PSQI) scores.
Athletic Performance and Muscle Recovery: For strength trainers, ashwagandha extract can significantly improve muscle strength and endurance. A 12-week study found that, combined with resistance training, participants' bench press and leg press strength increased by 46% and 44%, respectively, while levels of muscle damage markers CK and LDH were significantly reduced.
Immune Modulation: Ashwagandha extract enhances the body's immunity by regulating the Th1/Th2 balance and increasing NK cell activity. Studies show that 30 days of continuous supplementation can increase immunoglobulin IgG levels by 15.3%.
Cognitive Function Enhancement: By promoting neuronal regeneration and synaptic plasticity, ashwagandha extract can improve attention, memory, and information processing speed. A double-blind controlled trial involving 50 adults showed that after 8 weeks of supplementation, participants' cognitive test scores improved by 18.7%.
Improved Sleep Quality: Ashwagandha extract powder regulates GABA receptor activity, extending deep sleep duration and reducing sleep latency. Studies show that insomniac patients who took 120mg of standardized extract nightly experienced a 72% improvement in their Pittsburgh Sleep Quality Index (PSQI) scores.
Athletic Performance and Muscle Recovery: For strength trainers, ashwagandha extract can significantly improve muscle strength and endurance. A 12-week study found that, combined with resistance training, participants' bench press and leg press strength increased by 46% and 44%, respectively, while levels of muscle damage markers CK and LDH were significantly reduced.
Immune Modulation: Ashwagandha extract enhances the body's immunity by regulating the Th1/Th2 balance and increasing NK cell activity. Studies show that 30 days of continuous supplementation can increase immunoglobulin IgG levels by 15.3%.
Examples of withanolides in dietary supplements
Stress Management Formula: A typical product like "Stress Support Complex" contains 300mg of ashwagandha extract (5% standardized) + 200mg of L-theanine + 100mg of magnesium per capsule, specifically designed for stress management needs of working professionals.
Sports Nutrition Product: "Athletic Performance Blend" combines 400mg of ashwagandha extract with 5g of creatine and 2g of beta-alanine, targeting athletes and fitness enthusiasts to improve training adaptation and recovery speed.
Sleep Optimization Formula: "Restorative Sleep Formula" contains 250mg of ashwagandha extract, 3mg of melatonin, and 100mg of glycine, improving sleep structure and quality through multiple mechanisms.
Cognitive Enhancement Product: "Neuro-Enhance Complex" provides 350mg of ashwagandha extract, 150mg of phosphatidylserine, and 100mg of Ginkgo biloba extract per serving, specifically targeting the cognitive needs of students and those in demanding intellectual professions.
Sports Nutrition Product: "Athletic Performance Blend" combines 400mg of ashwagandha extract with 5g of creatine and 2g of beta-alanine, targeting athletes and fitness enthusiasts to improve training adaptation and recovery speed.
Sleep Optimization Formula: "Restorative Sleep Formula" contains 250mg of ashwagandha extract, 3mg of melatonin, and 100mg of glycine, improving sleep structure and quality through multiple mechanisms.
Cognitive Enhancement Product: "Neuro-Enhance Complex" provides 350mg of ashwagandha extract, 150mg of phosphatidylserine, and 100mg of Ginkgo biloba extract per serving, specifically targeting the cognitive needs of students and those in demanding intellectual professions.
Why choose SOST Biotech's Ashwagandha Withanolides powder?
Professional Extraction Technology: Utilizing ultrasonic-assisted extraction and membrane separation purification technology, we ensure the activity and stability of withanolides from Ashwagandha. Our standardized production process guarantees batch-to-batch consistency, with the withanolide content controlled within a ±2% margin of error.
Strict Quality Control: From raw material procurement to finished product delivery, we implement the HACCP quality management system throughout the entire process. Each batch of product undergoes more than 20 tests, including HPLC, GC-MS, heavy metals, and pesticide residue analysis, to ensure product safety and effectiveness.
Customized Services: We offer Ashwagandha withanolide products in various specifications, ranging from 1.5% to 12%, and can customize particle size, solubility, and formulation application solutions according to customer needs.
Strict Quality Control: From raw material procurement to finished product delivery, we implement the HACCP quality management system throughout the entire process. Each batch of product undergoes more than 20 tests, including HPLC, GC-MS, heavy metals, and pesticide residue analysis, to ensure product safety and effectiveness.
Customized Services: We offer Ashwagandha withanolide products in various specifications, ranging from 1.5% to 12%, and can customize particle size, solubility, and formulation application solutions according to customer needs.
Product Data Sheets
| Analysis | Description | Test Method |
| Appearance | Orange-Yellow Powder | Visual |
| Odor | Characteristic | Nasil |
| Identification | Conform with reference sample | HPLC |
| Mesh Size | 100% pass 80 mesh | CP2020 |
| Moisture Content | ≤ 1.0% | GB5009.3-2016 |
| Residue on Ignition | ≤ 0.5 % | CP2020 |
| Heavy Metals | ≤ 10 ppm | CP2020 |
| Arsenic (As) | ≤ 1.5 ppm | BS EN ISO17294-2 2016 2016 |
| Lead (Pb) | ≤ 2 ppm | BS EN ISO17294-2 2016 |
| Cadmium（Cd） | ≤1ppm | BS EN ISO17294-2 2016 |
| Mercury （Hg） | ≤1ppm | BS EN ISO17294-2 2016 |
| Methyl alcohol | 30ppm （Eurofins：LOQ ） | CP2020 |
| N,N-Dimethylformamide | 880ppm （Eurofins：LOQ ） | CP2020 |
| Total Plate Count | ≤10000 cfu/g | ISO 4833- 1:2013 |
| Yeast and Mold | ≤100 cfu/g | ISO 21527-2:2008 |
| Escherichia Coli | < 10cfu/g | ISO 16649-2:2001 |
| Salmonella/25g | Absent | ISO 6579-1:2017 |
| Effective constituent | Curcumin≥98% | HPLC |
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