Fisetin Powder Bulk

Fisetin foda girma flavonol ne na halitta wanda aka fara keɓe daga tsire-tsire na dangin Anacardiaceae, don haka sunansa. Kwayoyinsa kwarangwal na polyphenols, tare da sinadarai dabara na C₁₅H₁₀O₆, CAS No. 528-48-3, kuma shi ne kodadde rawaya zuwa kashe-fari crystalline foda. Ba shi da narkewa a cikin ruwa, amma cikin sauƙin narkewa a cikin kaushi na polar kamar acetone, ethanol, da dimethyl sulfoxide. A dabi'a, abinci irin su strawberries, apples, albasa, cucumbers, da fatun innabi duk sun ƙunshi adadin Fisetin, amma jimlar adadin ya yi ƙasa sosai - Masanan Japan sun ƙididdige cewa matsakaicin abincin yau da kullun ga mutum kusan 0.4 MG ne kawai. Idan kana son taka rawar gani sosai a cikin binciken kimiyya ko abinci mai aiki, yawanci kuna buƙatar albarkatun "Fisetin foda" tare da tsabta na ≥98%, wanda aka samu ta hanyar matakai kamar hakar ɗanyen Cotinus coggygria ko strawberry, chromatography refining, da recrystallization, sa'an nan kuma cancanta ta hanyar HPLC na waje daidaitattun aikace-aikace kafin ya iya shigar da aikace-aikace na waje na HPLC.

Ɗaya daga cikin abubuwan da aka fi sani da cututtuka na cututtukan neurodegenerative irin su cutar Alzheimer (AD) da cutar Parkinson (PD) shine neuroinflammation na kullum. Fisetin yana rage sakin proinflammatory cytokines TNF-α, IL-1β, da IL-6 ta hanyar hana hanyar siginar NF-κB, don haka rage "buga na biyu" wanda ya haifar da wuce kima na kunna microglia.

Gwaje-gwajen dabba sun nuna cewa Fisetin na iya kunna hanyar ERK / CREB, ƙara yawan maganganun sunadaran synapsin I da PSD95, da haɓaka ƙarfin lokaci mai tsawo (LTP), wanda a ƙarshe ya bayyana a matsayin haɓakawa a cikin koyo da ƙarfin ƙarfafa ƙwaƙwalwar ajiya.

A cikin nau'in mice na AD transgenic, ci gaba da gudanar da Fisetin foda 25 mg / kg na watanni 3 na iya rage girman yanki na plaques Aβ42 a cikin hippocampus da jujjuya ƙarancin ƙwaƙwalwar ajiya.

An nuna Fisetin don daidaita maganganun SIRT1, haɓaka aikin mitochondrial, da jinkirta tsufa na cell. Wannan tsarin ba wai kawai yana da alaƙa da neuroprotection ba, amma kuma ana la'akari da sabon manufa don binciken rigakafin tsufa.

Ƙananan kashi (≤25 mg/rabo) za'a iya amfani dashi azaman sinadari na "tallafin ƙwaƙwalwar ajiya" kuma ƙara zuwa sandunan kuzari da shirye-shiryen sha mai aiki.

Yin amfani da kaddarorin antioxidant masu ƙarfi, za a iya ƙara foda fisetin zuwa creams da essences don magance damuwa na oxidative na fata da rage ɗaukar hoto.

CMS121 na asali tare da fisetin azaman asalin mahaifa an ƙaddamar da shi a cikin Amurka don maganin AD a cikin gwaje-gwajen Mataki na I kuma yana iya shiga kasuwar magani a nan gaba.

Fisetin foda mai tsabta mai tsabta yana amfani da shi sosai a cikin ƙirar ƙwayar cuta ta kwayar halitta da gwaje-gwajen halayyar dabba don nazarin hanyoyin cutar Alzheimer, cutar Parkinson, da kuma amyotrophic lateral sclerosis (ALS).

Nazarin farko sun gano cewa fisetin foda zai iya yin yaki da cututtuka na cututtuka na kullum (CTE) wanda ya haifar da rikice-rikice da yawa ta hanyar hana neuroinflammation da inganta abubuwan neurotrophic.