Fisetin Foda Mai Yawa

Babban foda na Fisetin flavonol ne na halitta wanda aka fara ware shi daga tsire-tsire na dangin Anacardiaceae, shi ya sa aka sanya masa suna. Kwayar halittarsa ​​ta ƙunshi polyphenols, tare da dabarar sinadarai ta C₁₅H₁₀O₆, CAS No. 528-48-3, kuma foda ne mai launin rawaya zuwa fari. Ba ya narkewa a cikin ruwa, amma yana narkewa cikin sauƙi a cikin abubuwan da ke narkewa kamar acetone, ethanol, da dimethyl sulfoxide. A yanayi, abinci kamar strawberries, apples, albasa, kokwamba, da fatar innabi duk suna ɗauke da ƙaramin adadin Fisetin, amma jimlar adadin yana da ƙasa sosai - masana Japan sun ƙididdige cewa matsakaicin abincin da mutum ke ci kowace rana shine kusan 0.4 mg kawai. Idan kana son taka rawa a cikin binciken kimiyya ko abinci mai aiki, yawanci kana buƙatar kayan da aka yi da "Fisetin foda" mai tsarkin ≥98%, wanda ake samu ta hanyar hanyoyin kamar cire ɗanyen Cotinus coggygria ko strawberry, gyaran chromatography, da sake yin amfani da shi, sannan a sami cancantar ta hanyar hanyar HPLC ta waje kafin a iya shigar da shi a ƙasa.

Ɗaya daga cikin abubuwan da suka fi haifar da cututtukan jijiyoyi kamar cutar Alzheimer (AD) da cutar Parkinson (PD) shine kumburin jijiyoyi na yau da kullun. Fisetin yana rage sakin cytokines masu hana kumburi TNF-α, IL-1β, da IL-6 ta hanyar hana hanyar siginar NF-κB, ta haka yana rage "busa ta biyu" da ke faruwa sakamakon yawan kunna ƙwayoyin cuta.

Gwaje-gwajen dabbobi sun nuna cewa Fisetin na iya kunna hanyar ERK/CREB, ƙara yawan bayyanar sunadaran synaptic synapsin I da PSD95, da kuma haɓaka ƙarfin lokaci mai tsawo (LTP), wanda a ƙarshe yake bayyana a matsayin ci gaba a cikin iyawar koyo da ƙarfafa ƙwaƙwalwa.

A cikin berayen AD transgenic model, ci gaba da shan foda Fisetin 25 mg/kg na tsawon watanni 3 na iya rage yankin plaques na Aβ42 a cikin hippocampus da kuma mayar da ƙarancin ƙwaƙwalwar ajiya.

An nuna cewa Fisetin yana ƙara yawan bayyanar SIRT1, yana ƙara aikin mitochondrial, da kuma jinkirta tsufan ƙwayoyin halitta. Wannan tsari ba wai kawai yana da alaƙa da kare ƙwayoyin jijiyoyi ba, har ma ana ɗaukarsa a matsayin sabon abin da ake sa ran yi don binciken hana tsufa.

Ana iya amfani da ƙaramin allurai (≤25 mg/rabo) a matsayin sinadari na "taimakon ƙwaƙwalwa" sannan a ƙara shi a cikin sandunan makamashi da abubuwan sha masu aiki waɗanda ake shirin sha.

Ta hanyar amfani da ƙarfin sinadarin antioxidants, ana iya ƙara foda fisetin a cikin man shafawa da abubuwan da ke cikinsa don magance damuwar oxidative fata da rage tsufan fata.

An ƙaddamar da samfurin CMS121 mai ɗauke da fisetin a matsayin tushen iyaye a Amurka don maganin AD a cikin gwaje-gwajen Mataki na I kuma yana iya shiga kasuwar magunguna ta hanyar likita a nan gaba.

Ana amfani da foda fisetin mai tsarki sosai a cikin samfuran damuwa na oxidative na ƙwayoyin halitta da gwaje-gwajen halayen dabbobi don nazarin hanyoyin cutar Alzheimer, cutar Parkinson, da amyotrophic lateral sclerosis (ALS).

Binciken farko ya gano cewa foda na fisetin na iya yaƙar cutar encephalopathy mai tsanani (CTE) wanda ke faruwa sakamakon maimaita bugun zuciya ta hanyar hana kumburin jijiyoyi da kuma haɓaka abubuwan da ke haifar da jijiyoyin jini.