ʻO ka pauka Spermidine

Hoʻolauna Huahana

• ʻO Spermidine, i kapa ʻia ʻo spermidine trihydrochloride, he polyamine. Hoʻolaha nui ʻia i nā mea ola a ua biosynthesized mai putrescine (butanediamine) a me adenosylmethionine. Hiki i ka Spermidine ke kāohi i ka neuronal synthase, hoʻopaʻa a hoʻopaʻa i ka DNA; hiki ke hoʻohana ʻia e hoʻomaʻemaʻe i nā protein paʻa DNA a hoʻoulu i ka hana T4 polynucleotide kinase. Ma ka lā 1 o Kepakemapa, 2013, ua hui pū nā kānaka ʻepekema mai Kelemānia a me Austria i ka noiʻi ʻana a ʻōlelo ʻia e hiki i ka spermidine ke pale i ka hoʻomaka ʻana o ka maʻi o Alzheimer.
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Kaʻina Hana Hana

Hana Huahana

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• Hiki i ka Spermidine ke hoʻopaneʻe i ka ʻelemakule protein. No ka mea hiki ke pāʻani like ʻole nā protein o nā kaupaona ʻokoʻa i ke kaʻina hana o ka ʻelemakule, hiki i kekahi mau protein kaumaha molekala nui ke pāʻani i ke kuleana koʻikoʻi i ka hoʻomalu ʻana i ke kaʻina o ka ulu ʻana o nā lau. I ka wā e hoʻomaka ai ka hoʻohaʻahaʻa ʻana o kēia mau protein, ʻaʻole hiki ke ʻike ʻia ka senescence, a he paʻakikī ke kāohi i ka hoʻohaʻahaʻa ʻana o kēia mau protein. Hiki ke hoʻopaneʻe i ke kaʻina hana ʻelemakule. ʻO ke kumu e hiki ai i ka spermidine ke hoʻopaneʻe i ka ʻelemakule, ʻo ia ke hoʻoikaika i ka synthesis o kēia mau protein a i ʻole e pale i ko lākou hōʻino ʻana.

Hoʻohana Huahana

• ʻO Spermidine kahi carbide aliphatic haʻahaʻa haʻahaʻa i loaʻa i ʻekolu pūʻulu amine a ʻo ia kekahi o nā polyamines maoli i loaʻa i nā mea ola āpau. He mea koʻikoʻi ia no ka synthesis lāʻau lapaʻau a hoʻohana nui ʻia i ka synthesis o nā intermediates pharmaceutical.

  
  

  Hoʻokomo ʻia ʻo Spermidine i nā kaʻina hana olaola he nui i loko o nā mea ola, e like me ka hoʻoponopono ʻana i ka hoʻonui ʻana o ka cell, cell senescence, hoʻomohala ʻana i ke kino, immunity, cancer and other physiological and pathological process. Ua hōʻike ʻia nā haʻawina hou he hana koʻikoʻi ka spermidine i nā kaʻina hana e like me ka synaptic plasticity, oxidative stress, a me ka autophagy i loko o ka ʻōnaehana nerve.
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