Fisetin Powder Bulk

Fisetin hmoov bulk yog lub ntuj flavonol uas yog thawj zaug cais tawm ntawm cov nroj tsuag ntawm tsev neeg Anacardiaceae, yog li nws lub npe. Nws cov pob txha molecular belongs rau polyphenols, nrog rau cov tshuaj formula C₁₅H₁₀O₆, CAS No. 528-48-3, thiab yog daj ntseg daj mus rau dawb crystalline hmoov. Nws yog insoluble hauv dej, tab sis yooj yim soluble nyob rau hauv polar solvents xws li acetone, ethanol, thiab dimethyl sulfoxide. Nyob rau hauv qhov xwm txheej, cov khoom noj xws li txiv pos nphuab, txiv apples, dos, dib, thiab txiv hmab txiv ntoo tawv tag nrho muaj cov lej ntawm Fisetin, tab sis tag nrho cov nyiaj qis heev - Cov kws tshawb fawb Nyij Pooj tau suav tias qhov nruab nrab ntawm kev noj haus txhua hnub rau ib tus neeg tsuas yog txog 0.4 mg. Yog tias koj xav ua lub luag haujlwm meej hauv kev tshawb fawb txog kev tshawb fawb lossis khoom noj khoom haus, feem ntau koj xav tau "Fisetin hmoov" raw khoom nrog purity ntawm ≥98%, uas yog tau los ntawm cov txheej txheem xws li crude extraction ntawm Cotinus coggygria los yog strawberry, chromatography refining, thiab recrystallization, thiab tom qab ntawd tsim nyog los ntawm HPLC sab nrauv txheej txheem kev siv.

Ib qho ntawm cov kab mob ntawm cov kab mob neurodegenerative xws li Alzheimer's disease (AD) thiab Parkinson's disease (PD) yog mob neuroinflammation. Fisetin txo qhov kev tso tawm ntawm proinflammatory cytokines TNF-α, IL-1β, thiab IL-6 los ntawm inhibiting NF-κB signaling pathway, yog li txo qhov "secondary blow" los ntawm kev ua kom ntau dhau ntawm microglia.

Cov kev sim tsiaj tau pom tias Fisetin tuaj yeem qhib txoj hauv kev ERK / CREB, nce kev qhia ntawm synaptic proteins synapsin I thiab PSD95, thiab txhim kho kev muaj peev xwm mus sij hawm ntev (LTP), uas thaum kawg tshwm sim raws li kev txhim kho hauv kev kawm thiab kev nco txog kev muaj peev xwm.

Hauv AD transgenic qauv nas, kev tswj hwm tas li ntawm Fisetin hmoov 25 mg / kg rau 3 lub hlis tuaj yeem txo qhov chaw ntawm Aβ42 plaques hauv hippocampus thiab rov qab nco tsis txaus.

Fisetin tau pom tias yuav txhim kho SIRT1 kev qhia, txhim kho mitochondrial muaj nuj nqi, thiab ncua kev laus ntawm tes. Cov txheej txheem no tsis yog tsuas yog cuam tshuam nrog neuroprotection, tab sis kuj suav tias yog lub hom phiaj tshiab rau kev tshawb fawb los tiv thaiv kev laus.

Cov koob tshuaj tsawg (≤25 mg / feem) tuaj yeem siv los ua "kev txhawb nqa kev nco" cov khoom xyaw thiab ntxiv rau lub zog tuav thiab npaj cov dej haus ua haujlwm.

Siv nws cov khoom muaj zog antioxidant, fisetin hmoov tuaj yeem ntxiv rau cov cream thiab cov ntsiab lus los tawm tsam cov tawv nqaij oxidative kev nyuaj siab thiab txo cov duab.

Lub derivative CMS121 nrog fisetin raws li niam txiv tseem ceeb tau raug tsim tawm hauv Tebchaws Meskas rau kev kho mob ntawm AD hauv Phase I sim thiab tuaj yeem nkag mus rau hauv khw muag tshuaj rau yav tom ntej.

High-purity fisetin hmoov yog siv dav hauv cov qauv ntawm tes oxidative kev nyuaj siab thiab kev sim tsiaj txhu los kawm txog cov txheej txheem ntawm Alzheimer's disease, Parkinson's disease, thiab amyotrophic lateral sclerosis (ALS).

Cov kev tshawb fawb ua ntej tau pom tias fisetin hmoov tuaj yeem tua cov kab mob encephalopathy mob ntev (CTE) tshwm sim los ntawm kev rov qab ua dua los ntawm inhibiting neuroinflammation thiab txhawb cov neurotrophic yam.