Hesperidin Hmoov

Hesperidin yog ib qho dihydroflavonoid glycoside nrog cov mis molecular C29H33O15 thiab qhov hnyav molecular ntawm 610.56. Hesperidin ntshiab zoo li cov siv lead dawb zoo li koob, thaum cov kua rho tawm feem ntau yog cov hmoov crystalline xim av tsaus. Thawj zaug rho tawm ntawm cov tev txiv qaub hauv xyoo 1828, nws yog cov khoom xyaw tseem ceeb ntawm vitamin P (permeability vitamin), uas tau txais nws lub npe "natural vitamin P". Hesperidin tau muab faib dav hauv xwm: 30% -50% pom muaj nyob rau hauv daim tawv nqaij, pericarp thiab tev ntawm cov txiv hmab txiv ntoo qhuav citrus, thiab kwv yees li 1% -5% pom muaj nyob rau hauv tev. Kev tsim khoom lag luam niaj hnub no siv cov txiv hmab txiv ntoo ua cov khib nyiab, tev thiab pericarps ua cov khoom siv raw. Los ntawm alkaline extraction thiab acid precipitation, ultrasonic-assisted extraction lossis ion exchange, hesperidin tau concentrated rau ntau dua 90% thiab tom qab ntawd tsuag-qhuav rau hauv kua hesperidin hmoov.

Dej: Yuav tsum siv li 50 liv dej ntshiab ntawm 25°C kom yaj tag 1 gram ntawm hesperidin hmoov; qhov solubility nce me ntsis hauv dej kub saum 70°C.

Cov kuab tshuaj organic: Yooj yim yaj hauv pyridine, dimethylformamide thiab sodium hydroxide kua; me ntsis yaj hauv glacial acetic acid thiab methanol; tsis yaj hauv acetone, benzene, chloroform thiab ether.

Kev rhiab heev ntawm pH: Hauv cov tshuaj alkaline (pH > 9), nws qhib nrog lub nplhaib uas tsim lawv, uas ua rau nws cov solubility sai dua. Thaum pH rov qab mus rau qib acidic, nws kaw dua thiab o. Yog li ntawd, "alkaline dissolution thiab acid precipitation" yog ib txoj kev siv ntau rau kev ntxuav cov hmoov hesperidine hauv chav kuaj.

Qhov tseem ceeb ntawm cov txheej txheem: Vim nws cov dej tsis yaj zoo, cov hmoov hesperidine ib txwm yooj yim precipitated hauv cov kab ke aqueous heev xws li dej haus thiab cov kua hauv qhov ncauj. Kev koom ua ke ntawm hydroxypropyl-β-cyclodextrin, cov khoom tawg, lossis cov txheej txheem microemulsification feem ntau siv hauv kev lag luam los txhim kho nws cov dej tawg ruaj khov thiab xyuas kom meej tias cov khoom kawg huv thiab meej.

"Glycosides" thiab "glycosides" yog cov npe qub thiab tshiab:
• Cov npe qub: "Glycosides" hauv hesperidin yog txhais los ntawm lus Nyiv Pooj xyoo 1950;
• Lub npe tshiab: Tom qab xyoo 1990, Pawg Neeg Saib Xyuas Kev Tshawb Fawb ntawm kuv lub teb chaws tau hloov lo lus "glycosides" mus rau lo lus txhais tau tias "glycosides", ua rau lub npe "hesperidin".

Yog li ntawd, hauv cov ntawv xov xwm kev kawm, cov ntawv sau tshuaj thiab cov qauv thoob ntiaj teb, tam sim no nws raug sau ua "hesperidin" tib yam. Txawm li cas los xij, qee cov ntaub ntawv qub thiab qee cov kws ua haujlwm thaum ub tseem siv lo lus "hesperidin". Ob qho tib si muaj cov qauv tshuaj thiab cov lej CAS (520-26-3), thiab lawv tuaj yeem suav tias yog tib yam khoom. Nws yog ib qho tseem ceeb uas yuav tsum nco ntsoov tias cov lus "Hesperidin = Hesperidin-7-O-rutinoside" thiab "Hesperidin = Hesperidin-7-O-neohesperidin" uas koj qee zaum pom hauv online yog qhov tseeb tsis raug ntawm "Hesperidin thiab Neohesperidin" thiab yuav tsum tsis txhob tsis meej pem.

Yog tias koj tab tom nrhiav qib zaub mov lossis USP hesperidine hmoov, thov hu rau SOST Biotech, lub chaw tsim khoom cog qoob loo. Lub chaw ua haujlwm hauv Hoobkas nyob hauv thaj chaw high-tech ntawm Xi'an. Nws muaj chav kuaj GMP thiab cov chaw kuaj HPLC thiab GC-MS tiav. Feem ntau nws muaj peb qhov kev qhia tshwj xeeb: 90%, 95%