Cov Khoom Xyaw Tshuaj
Huperzine A Hmoov yog dab tsi?
Huperzine A hmoov yog ib qho tshuaj acetylcholinesterase inhibitor uas muaj cov tshuaj C11H1₈N2O uas yog ib yam khoom ntuj, hloov tau yooj yim, thiab xaiv tau zoo heev rau tiam thib ob. Nws zoo li yog hmoov dawb me ntsis lossis dawb crystalline ntawm chav tsev kub thiab yooj yim yaj hauv chloroform thiab methanol thiab yaj me ntsis hauv dej. Vim nws qhov hnyav molecular qis thiab lipid solubility siab, nws sai sai hla cov ntshav-lub hlwb barrier thiab accumulates hauv cov cheeb tsam hlwb ze rau kev kawm thiab kev nco, xws li lub hauv paus pem hauv ntej, cortex, thiab hippocampus. Kev txwv tsis pub acetylcholinesterase ua haujlwm ua rau muaj acetylcholine ntau ntxiv hauv synaptic cleft, yog li ua rau muaj kev sib kis neuronal excitatory thiab txhim kho kev nco thiab kev khaws cia. Clinically, Huperzine A hmoov, ntsiav tshuaj, capsules, thiab freeze-dried hmoov txhaj tshuaj yog siv dav ua kev kho mob adjunctive rau kev nco poob, Alzheimer's kab mob (AD), vascular dementia, thiab myasthenia gravis.
COA
| Khoom | Cov Lus Qhia Tshwj Xeeb | Cov txheej txheem |
| Kev piav qhia | Hmoov zoo | Cov tshuaj lom neeg |
| Xim | Hmoov dawb | Pom kev |
| Kev Ntsuas (%) | NLT 99% | HPLC |
| Poob thaum ziab (%) | NMT 5% | 5g / 105 ℃ /4 teev |
| Qhov loj ntawm daim ntaub | 95% dhau 80 mesh | USP |
| COV HNYAV | ≤10.00mg/Kg | USP |
| Pb | ≤2.00 mg/Kg | AAS |
| Raws li | ≤1.00 mg/Kg | AAS |
| Hg | ≤1.00 mg/Kg | AAS |
| Cd | ≤1.00 mg/Kg | AAS |
| Cov ntsiab lus tshauv (%) | NMT 5% | 2g / 525 ℃ / 3 teev |
| Tag Nrho Cov Kab Mob | ≤1000cfu/g | USP30 |
| Poov xab & pwm | ≤100cfu/g | USP30 |
| Kab mob Salmonella | Tsis zoo | USP30 |
| E. coli | Tsis zoo | USP30 |
| Kev txheeb xyuas | HPLC/UV-VIS/GC | |
| Kev Khaws Cia | Khaws cia rau hauv qhov chaw txias thiab qhuav, khaws cia kom deb ntawm lub teeb thiab cua sov. | |
| Lus Cim | Lub neej txee: Ob xyoos thaum khaws cia kom zoo. | |
Cov koob tshuaj thiab kev tswj hwm ntawm Huperzine A
Huperzine A yog ib qho alkaloid tshiab uas tau rho tawm los ntawm cov nroj tsuag Melaleuca ntawm genus Melaleuca. Nws muaj cov haujlwm cholinomimetic muaj zog thiab yog ib qho tshuaj cholinesterase inhibitor uas ua haujlwm tau zoo thiab thim rov qab tau. Los ntawm kev txwv cholinesterase, nws txwv tsis pub acetylcholine puas tsuaj thiab ua rau nws cov haujlwm ntau ntxiv, uas yuav txhim kho kev sib kis ntawm cov neurotransmitter. Cov kev mob tshwm sim tseem ceeb yog ntuav thiab cem quav.
Nws yog siv rau hauv kev kho mob los kho tus kab mob Alzheimer. Tus kab mob Alzheimer yog ib qho kab mob uas ua rau lub paj hlwb puas tsuaj uas feem ntau tshwm sim rau cov neeg hnub nyoog tshaj 60 xyoo thiab muaj qhov pib tsis zoo. Nws tuaj yeem tshwm sim ua kev puas siab puas ntsws thiab kev hloov pauv tus cwj pwm. Tsis muaj kev kho mob tshwj xeeb. Cov tshuaj uas txhim kho kev zom zaub mov hauv lub hlwb thiab txhim kho kev ncig ntshav tuaj yeem siv tau thaum ntxov. Donepezil thiab Shishanmaine A kuj tseem siv tau.
Kev tswj hwm kev tshawb fawb ntawm huperzine A
Cov tshuaj noj
Cov ntsiav tshuaj/tshuaj ntsiav Huperzine A: Cov koob tshuaj ib txwm muaj: 50 mcg (0.05 mg) ib ntsiav tshuaj (tshuaj ntsiav).
• Kev tsis nco qab, tus kab mob Alzheimer: 0.1–0.2 mg (2–4 ntsiav tshuaj) ob zaug ib hnub, noj nrog dej sov tom qab noj tshais thiab noj su. Lub sijhawm kho mob yog 4-6 lub lis piam, thiab 1-2 zaug kev kho mob tuaj yeem txuas ntxiv mus raws li qhov ua tau zoo thiab kev kam rau siab.
• Cov neeg laus uas noj qab nyob zoo uas xav txhim kho kev kawm thiab kev ua tau zoo: Pib nrog 50 mcg thaum sawv ntxov thaum lub plab khoob. Tom qab 3 txog 5 hnub, nce mus rau 100 mcg ob zaug hauv ib hnub tshwj tsis yog tias muaj kev tsis xis nyob loj. Qhov ntau tshaj plaws txhua hnub yuav tsum tsis pub tshaj 0.45 mg (9 ntsiav tshuaj).
• Yog tias muaj cov tsos mob ntawm kev ua kom cholinergic xws li xeev siab, ntuav, thiab raws plab, txo qhov koob tshuaj lossis tsum tsis txhob siv tshuaj tam sim ntawd. Cov tsos mob feem ntau ploj mus ntawm lawv tus kheej hauv 24 teev.
Kev Txhaj Tshuaj Molding
Huperzine Khov-qhuav hmoov rau kev txhaj tshuaj: 0.2 mg / vial lossis 0.4 mg / vial.
• Kev puas siab puas ntsws: 0.2 mg yaj rau hauv 2 mL dej huv los ntawm kev txhaj tshuaj thiab txhaj rau hauv cov leeg ib zaug ib hnub rau 2-4 lub lis piam, tom qab ntawd hloov mus rau kev noj tshuaj.
• Mob Myasthenia gravis: 0.2-0.4 mg intramuscularly ib zaug ib hnub rau 4-6 lub lis piam, lossis raws li tus kws kho mob hais.
• Kev txhaj tshuaj sai, Tmax li 10-30 feeb thiab bioavailability >95%. Txawm li cas los xij, qhov no yuav tsum tau ua nyob rau hauv kev saib xyuas ntawm tsev kho mob lossis tus kws kho mob tsim nyog kom tsis txhob muaj kev phiv xws li mob hauv zos thiab o.
Cov nyhuv ntawm huperzine A hmoov rau kev pw tsaug zog
Feem ntau: cov tshuaj noj tsawg tsawg (0.05–0.1 mg) tsis cuam tshuam rau kev pw tsaug zog; hloov chaw, lawv tuaj yeem txhim kho qhov zoo ntawm kev pw tsaug zog los ntawm kev txhim kho kev ua haujlwm ntawm lub hlwb thaum nruab hnub thiab txo kev ntxhov siab.
Cov neeg noj tshuaj ntau dua lossis cov neeg uas muaj kev ua xua: Tom qab noj ib zaug xwb > 0.3 mg, qee tus neeg muaj cov tsos mob ntawm cholinergic hyperactivity xws li pw tsis tsaug zog ntev, mob plab thaum sawv ntxov ntau ntxiv.
Kuv yuav tau cov hmoov huperzine A qhov twg?
Yog tias koj tab tom nrhiav cov hmoov huperzine A zoo, koj tuaj yeem tiv tauj Xi'an SOST Biotech Co., Ltd. ("SOST Biotech"), tus kws tshaj lij kev muag khoom cog qoob loo. SOST Biotech ua haujlwm lub chaw cGMP-certified thiab tau txais HACCP thiab ISO22000 certified. Nws muab cov hmoov chrysin nrog qhov huv tshaj 98%. Cov qauv ntim suav nrog 1 kg txhuas ntawv ci hnab thiab 25 kg cardboard nruas. Peb kuj muab cov kev pabcuam OEM rau cov tshuaj ntsiav, ntsiav tshuaj, thiab dej haus khov.
>>> Nyem qhov no kom tau txais cov ntaub ntawv ntxivTiv tauj peb
Cov Ntawv Qhia Txog Khoom
| Khoom | Cov Lus Qhia Tshwj Xeeb | Cov txheej txheem |
| Kev piav qhia | Hmoov zoo | Cov tshuaj lom neeg |
| Xim | Hmoov dawb | Pom kev |
| Kev Ntsuas (%) | NLT 99% | HPLC |
| Poob thaum ziab (%) | NMT 5% | 5g / 105 ℃ /4 teev |
| Qhov loj ntawm daim ntaub | 95% dhau 80 mesh | USP |
| COV HNYAV | ≤10.00mg/Kg | USP |
| Pb | ≤2.00 mg/Kg | AAS |
| Raws li | ≤1.00 mg/Kg | AAS |
| Hg | ≤1.00 mg/Kg | AAS |
| Cd | ≤1.00 mg/Kg | AAS |
| Cov ntsiab lus tshauv (%) | NMT 5% | 2g / 525 ℃ / 3 teev |
| Tag Nrho Cov Kab Mob | ≤1000cfu/g | USP30 |
| Poov xab & pwm | ≤100cfu/g | USP30 |
| Kab mob Salmonella | Tsis zoo | USP30 |
| E. coli | Tsis zoo | USP30 |
| Kev txheeb xyuas | HPLC/UV-VIS/GC | |
| Kev Khaws Cia | Khaws cia rau hauv qhov chaw txias thiab qhuav, khaws cia kom deb ntawm lub teeb thiab cua sov. | |
| Lus Cim | Lub neej txee: Ob xyoos thaum khaws cia kom zoo. | |
Ntim & Xa Khoom
Peb Ua Tau Dab Tsi?
