Upfu hweHesperidin

Hesperidin idihydroflavonoid glycoside ine molecular formula C29H33O15 uye huremu hwemorekuru hwe610.56. Hesperidin yakachena inoonekwa semakristaro machena akafanana netsono, nepo crude extract inowanzova upfu hwebrown brown crystalline. Yakatanga kubviswa kubva mu citrus peel muna 1828, ndiyo chinhu chikuru chinoshanda chevhitamini P (vhitamini inobvumidzwa kupinda), izvo zvakaita kuti izitwe kuti "natural vitamin P". Hesperidin yakapararira zvakanyanya muzvisikwa: 30%–50% inowanikwa muganda, pericarp uye peel yemichero yakaomeswa yecitrus, uye inenge 1%–5% inowanikwa mupeel. Kugadzirwa kwemaindasitiri emazuva ano kunoshandisa marara ekugadzira michero yecitrus, peel uye pericarps sezvinhu zvakabikwa. Nekubvisa alkaline uye acid precipitation, ultrasonic-assisted extraction kana ion exchange, hesperidin yakawedzerwa kusvika kupfuura 90% uye yozopfapfaidzwa kuita liquid hesperidin powder.

Mvura: Marita angangoita makumi mashanu emvura yakachena pa25°C anodiwa kuti anyungudise 1 gramu yehupfu hwehesperidin; kunyungudika kunowedzera zvishoma mumvura inopisa pamusoro pe70°C.

Zvinonyungudutsa zvemuchadenga: Zvinonyunguduka zviri nyore mu pyridine, dimethylformamide uye sodium hydroxide solution; zvinonyunguduka zvishoma mu glacial acetic acid ne methanol; hazvinyunguduke mu acetone, benzene, chloroform ne ether.

Kunzwisiswa kwepH: Mumvura ine alkaline (pH > 9), inovhurika nerin'i inoiumba, iyo inowedzera kunyunguduka kwayo nekukurumidza. Kana pH yadzoka padanho reacidic, inovhara zvakare yozvimba. Saka, "alkaline dissolving uye acid precipitation" inzira inowanzo shandiswa pakuchenesa hesperidine powder murabhoritari.

Kukosha kwemaitiro: Nekuda kwekusanyunguduka kwayo mumvura, hupfu hwehesperidine hunowanikwa nyore nyore muzvinhu zvine mvura yakawanda zvakaita sezvinwiwa nezvinwiwa zvinonwiwa. Kushandiswa kwehydroxypropyl-β-cyclodextrin, solid dispersion, kana microemulsification matekiniki anowanzo shandiswa muindasitiri iyi kuvandudza kugadzikana kwayo mumvura uye kuona kuchena uye kujeka kwechigadzirwa chekupedzisira.

"Glycosides" uye "glycosides" ndezvemhando dzemazita ekare neetsva:
• Mazita ekare: "Glycosides" mu hesperidin inoshandurwa kubva muchiJapani muma1950;
• Zita idzva: Mushure mema1990, Komiti yeSainzi yeMashoko eMunyika yangu yakachinja izwi rekuti "glycosides" kuita izwi rimwechete rekuti "glycosides", zvikaita kuti zita rekuti "hesperidin".

Nekuda kweizvozvo, mumajenari edzidzo, mapharmacopoeias uye zviyero zvepasi rose, ikozvino yakanyorwa se "hesperidin" nenzira imwecheteyo. Zvisinei, mamwe mabhuku ekare nemamwe mainjiniya ekare achiri kushandisa izwi rekuti "hesperidin". Ava vaviri vane chimiro chemakemikari chakafanana uye nhamba dzeCAS (520-26-3), uye vanogona kunzi chinhu chimwe chete. Zvakakosha kuziva kuti mazwi ekuti "Hesperidin = Hesperidin-7-O-rutinoside" uye "Hesperidin = Hesperidin-7-O-neohesperidin" aunoona dzimwe nguva online anoreva kusanzwisiswa kwe "Hesperidin neNeohesperidin" uye haafanire kuvhiringidzwa.

Kana muchitsvaga upfu hwehesperidine hwemhando yepamusoro kana USP, ndapota taurai neSOST Biotech, nyanzvi yekugadzira zvinomera. Hofisi yefekitori iri munzvimbo yehunyanzvi hwepamusoro yeXi'an. Ine GMP lab uye ma laboratories akakwana ekuongorora HPLC neGC-MS. Inowanzova nematanho matatu: 90%, 95%