Budada Hesperidin

Hesperidin waa dihydroflavonoid glycoside oo leh caanaha molecular C29H33O15 iyo miisaanka kelli ee 610.56. Hesperidin saafi ah waxay u muuqataa sida kiristaalo irbad cad oo kale ah, halka laga soosaaray cayriin ay inta badan tahay budada crystalline brown madow. Markii ugu horeysay ee laga soocay diirka liinta 1828, waa walaxda ugu muhiimsan ee fitamiin P (fitamiinka permeability), taas oo kasbatay magaca "fitamiin P dabiiciga ah". Hesperidin si ballaaran ayaa loo qaybiyaa dabeecadda: 30%-50% waxaa laga helaa maqaarka, pericarp iyo diirka miraha liinta ee la qalajiyey, qiyaastii 1%-5% ayaa laga helaa diirka. Wax soo saarka warshadaha casriga ah waxay u isticmaashaa qashinka warshadaynta miraha liinta, qolofta iyo pericarps sida alaabta ceeriin. Soo saarista alkaline-ka iyo roobabka aashitada, soo saarista ultrasonic-caawin ama is-dhaafsiga ion, hesperidin waxaa la saaray in ka badan 90% ka dibna ku buufiyay-qallajiyey budada hesperidin dareere ah.

Biyaha: Qiyaastii 50 litir oo biyo saafi ah 25°C ayaa looga baahan yahay inay si buuxda u milmaan 1 garaam oo budada hesperidin ah; milmayshuhu wax yar buu ku kordhaa biyaha kulul ee ka sarreeya 70 ° C.

Walxaha dabiiciga ah: Si xor ah ugu milmay pyridine, dimethylformamide iyo sodium hydroxide; wax yar oo ku milma glacial acetic acid iyo methanol; aan lagu milmi karin acetone, benzene, chloroform iyo ether.

Dareenka pH: Xalalka alkaline-ka ah (pH> 9), waxay ku furtaa giraan iyaga ka dhigaya, taas oo si degdeg ah u kordhisa milmaheeda. Marka pH ay ku soo noqoto heerarka aashitada, mar kale ayay xirtaa oo bararaan. Sidaa darteed, "kala dirida alkaline iyo roobka aashitada" waa habka caadiga ah ee loo isticmaalo sifaynta budada hesperidine ee shaybaarka.

Muhiimadda geeddi-socod: Sababo la xiriira milmayntiisa biyaha oo liidata, budada hesperidine ee caadiga ah waxay si fudud ugu soo dagdagaysaa nidaamyada biyaha aadka u sarreeya sida cabitaannada iyo dareeraha afka. Isku darka hydroxypropyl-β-cyclodextrin, kala firdhisan adag, ama farsamooyinka microemulsification ayaa caadi ahaan loo isticmaalaa warshadaha si loo hagaajiyo xasilloonida kala firidhsan aqueous iyo in la hubiyo nadiifnimada iyo hufnaanta alaabta kama dambaysta ah.

"Glycosides" iyo "glycosides" waxay ka tirsan yihiin hababka magac-bixinta ee hore iyo kuwa cusub:
• Magacyadii hore: "Glycosides" ee hesperidin waxaa laga tarjumay Jabbaan 1950-meeyadii;
Magaca cusub: 1990-meeyadii ka dib, Guddiga Eray bixinta Sayniska ee dalkaygu waxay beddeleen ereyga "glycosides" oo la mid ah "glycosides", taasoo keentay magaca "hesperidin".

Natiijo ahaan, joornaalada akadeemiyada, farmashiyaha iyo heerarka caalamiga ah, hadda waxaa loo qoraa "hesperidin" si la mid ah. Si kastaba ha ahaatee, qaar ka mid ah suugaanta hore iyo qaar ka mid ah injineeradii hore ayaa weli isticmaala ereyga "hesperidin". Labadu waxay leeyihiin qaab-dhismeedka kiimikaad isku mid ah iyo lambarada CAS (520-26-3), waxaana loo qaadan karaa isku walax. Waxaa muhiim ah in la ogaado in ereyada "Hesperidin = Hesperidin-7-O-rutinoside" iyo "Hesperidin = Hesperidin-7-O-neohesperidin" ee aad mararka qaarkood ku aragto online ay dhab ahaantii si khaldan u fasirayaan "Hesperidin iyo Neohesperidin" oo waa in aan lagu jahwareerin.

Haddii aad raadinayso darajada cuntada ama budada hesperidine ee USP, fadlan la xidhiidh SOST Biotech, soo saaraha soosaarka dhirta. Xafiiska warshadu wuxuu ku yaalaa aagga farsamada sare ee Xi'an. Waxay leedahay shaybaadhka GMP oo dhamaystiran HPLC iyo GC-MS shaybaarada baadhista. Sida caadiga ah waxay leedahay saddex tilmaamood: 90%, 95%