Phofo ea Spermidine

Selelekela sa Sehlahisoa

• Spermidine, e tsejoang hape e le spermidine trihydrochloride, ke polyamine. E ajoa haholo linthong tse phelang 'me e entsoe ka biosynthesized ho tsoa ho putrescine (butanediamine) le adenosylmethionine. Spermidine e ka thibela neuronal synthase, ea tlama le ho potlakisa DNA; e ka boela ea sebelisoa ho hloekisa liprotheine tse tlamang DNA le ho susumetsa ts'ebetso ea T4 polynucleotide kinase. Ka la 1 Loetse, 2013, bo-rasaense ba tsoang Jeremane le Austria ba ile ba etsa lipatlisiso ka kopanelo 'me ba bolela hore spermidine e ka thibela ho qala ha lefu la Alzheimer's.
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Tsamaiso ea Ts'ebetso

Mosebetsi oa Sehlahisoa

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• Spermidine e ka liehisa botsofali ba protheine. Hobane liprotheine tsa boima bo fapaneng ba limolek'hule li ka bapala karolo e fapaneng ts'ebetsong ea botsofali, liprotheine tse ling tse kholo tsa boima ba limolek'hule li ka bapala karolo ea bohlokoa ho laoleng ts'ebetso ea botsofali ba makhasi. Hang ha liprotheine tsena li qala ho senyeha, botsofali bo ke ke ba qojoa, 'me ho thata ho laola ho senyeha ha liprotheine tsena. E ka liehisa ts'ebetso ea botsofali. Lebaka leo ka lona spermidine e ka liehisang botsofali e ka ba ho khothalletsa tlhahiso ea liprotheine tsena kapa ho thibela ho senyeha ha tsona.

Kopo ea Sehlahisoa

• Spermidine ke carbide e nang le boima bo tlase ba limolek'hule e nang le lihlopha tse tharo tsa amine 'me ke e' ngoe ea li-polyamine tsa tlhaho tse teng linthong tsohle tse phelang. Ke thepa ea bohlokoa e tala bakeng sa ho kopanya lithethefatsi 'me e sebelisoa haholo ho kopanyeng metsoako ea meriana.

  
  

  Spermidine e ameha lits'ebetsong tse ngata tsa baeloji linthong tse phelang, tse kang ho laola ho ata ha sele, botsofali ba sele, nts'etsopele ea litho, sesole sa 'mele, kankere le lits'ebetso tse ling tsa 'mele le tsa mafu. Lithuto tsa morao tjena li bontšitse hore spermidine e bapala karolo ea bohlokoa ea taolo lits'ebetsong tse kang synaptic plasticity, oxidative stress, le autophagy tsamaisong ea methapo.
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