Umgubo weHesperidin

IHesperidin yi-glycoside ye-dihydroflavonoid enefomula yemolekyuli i-C29H33O15 kunye nobunzima bemolekyuli obuyi-610.56. I-hesperidin ecocekileyo ibonakala njengeekristale ezimhlophe ezifana nenaliti, ngelixa i-crude extract ihlala ingumgubo wekristale omdaka omnyama. Yaqala ukususwa kwi-citrus peel ngo-1828, sisithako esisebenzayo esiphambili sevithamini P (ivithamini yokungena), eyathi yabizwa ngokuba yi "natural vitamin P". IHesperidin isasazeke kakhulu kwindalo: i-30%–50% ifumaneka eluswini, kwi-pericarp nakwixolo leziqhamo ze-citrus ezomisiweyo, kwaye malunga ne-1%–5% ifumaneka kwixolo. Imveliso yemizi-mveliso yanamhlanje isebenzisa inkunkuma yokucubungula iziqhamo ze-citrus, amaxolo kunye ne-pericarps njengezinto eziluhlaza. Ngokukhupha i-alkaline kunye ne-acid precipitation, ukukhupha okuncediswa yi-ultrasonic okanye ukutshintshana kwe-ion, i-hesperidin yayixutywe ngaphezulu kwe-90% ize yomiswe nge-spray ibe ngumgubo we-hesperidin omanzi.

Amanzi: Kufuneka malunga neelitha ezingama-50 zamanzi acocekileyo kwi-25°C ukuze kunyibilike ngokupheleleyo i-1 gram yomgubo we-hesperidin; ukunyibilika kunyuka kancinci emanzini ashushu angaphezu kwama-70°C.

Izinyibilikisi zendalo: Zinyibilika ngokukhululekileyo kwisisombululo se-pyridine, i-dimethylformamide kunye ne-sodium hydroxide; zinyibilika kancinci kwi-glacial acetic acid kunye ne-methanol; azinyibiliki kwi-acetone, i-benzene, i-chloroform kunye ne-ether.

Uvakalelo lwe-pH: Kwizisombululo ze-alkaline (pH > 9), ivula ngesangqa esizibumbayo, nto leyo enyusa ngokukhawuleza ukunyibilika kwayo. Xa i-pH ibuyela kumanqanaba e-asidi, iyavaleka kwakhona ize idumbe. Ke ngoko, "ukunyibilika kwe-alkaline kunye nokuchithwa kwe-asidi" yindlela esetyenziswa kakhulu ekucoceni umgubo we-hesperidine kwilebhu.

Ukubaluleka kwenkqubo: Ngenxa yokunganyibiliki kakuhle kwamanzi, i-hesperidine powder eqhelekileyo ifumaneka lula kwiinkqubo ezinamanzi amaninzi ezifana neziselo kunye nolwelo oluselwa ngomlomo. Ukufakwa kwe-hydroxypropyl-β-cyclodextrin, i-solid dispersion, okanye iindlela ze-microemulsification zisetyenziswa kakhulu kushishino ukuphucula uzinzo lwayo lokusasazeka kwamanzi kunye nokuqinisekisa ubunyulu kunye nokucaca kwemveliso yokugqibela.

"IiGlycosides" kunye "neeglycosides" zezinye zeenkqubo zokubiza ezindala nezintsha:
• Amagama amadala: "IiGlycosides" kwi-hesperidin ziguqulelwe ukusuka kwisiJapan ngeminyaka yoo-1950;
• Igama elitsha: Emva kweminyaka yoo-1990, iKomiti yeSayensi yeSizwe yelizwe lam yatshintsha igama elithi "glycosides" laba ligama elifanayo nelithi "glycosides", nto leyo eyabangela igama elithi "hesperidin".

Ngenxa yoko, kwiijenali zezemfundo, kwii-pharmacopoeias nakwimigangatho yamazwe ngamazwe, ngoku ibhalwa njenge-"hesperidin" ngendlela efanayo. Nangona kunjalo, ezinye iincwadi zakudala kunye neenjineli zamandulo zisasebenzisa igama elithi "hesperidin". Ezi zimbini zinesakhiwo esifanayo seekhemikhali kunye namanani e-CAS (520-26-3), kwaye zinokuthathwa njengezinto ezifanayo. Kubalulekile ukuqaphela ukuba amagama athi "Hesperidin = Hesperidin-7-O-rutinoside" kunye nelithi "Hesperidin = Hesperidin-7-O-neohesperidin" ozibona ngamanye amaxesha kwi-intanethi ngokwenene ziingcaciso ezingalunganga ze-"Hesperidin kunye ne-Neohesperidin" kwaye akufuneki zidideke.

Ukuba ufuna i-food grade okanye i-USP hesperidine powder, nceda unxibelelane ne-SOST Biotech, umenzi weemveliso zezityalo oqeqeshiweyo. Iofisi yefektri ikwindawo yobuchwepheshe obuphezulu yaseXi'an. Inelebhu ye-GMP kunye neelabhoratri zovavanyo ze-HPLC kunye ne-GC-MS ezipheleleyo. Ihlala ineenkcazo ezintathu: 90%, 95%