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Yintoni iHuperzine A Powder?
Umgubo weHuperzine A yi-acetylcholinesterase inhibitor yendalo, eguqulwayo, kwaye ikhethwa kakhulu kwisizukulwana sesibini se-acetylcholinesterase enefomyula yekhemikhali i-C11H1₈N2O. Ibonakala njengomgubo wekristale omhlophe kancinci okanye omhlophe kubushushu begumbi kwaye inyibilika ngokulula kwi-chloroform kunye ne-methanol kwaye inyibilika kancinci emanzini. Ngenxa yobunzima bayo obuphantsi beemolekyuli kunye nokunyibilika okuphezulu kwamafutha, inqumla ngokukhawuleza umqobo wegazi-ingqondo kwaye iqokelelana kwiindawo zobuchopho ezinxulumene nokufunda kunye nememori, njenge-frontal lobe, i-cortex, kunye ne-hippocampus. Ukuthintela umsebenzi we-acetylcholinesterase kwandisa uxinzelelo lwe-acetylcholine kwi-synaptic cleft, ngaloo ndlela kwandisa ukudluliselwa kwe-neuronal excitatory kunye nokuphucula ukugcinwa kwememori kunye nokubuyiswa kwayo. Ngokwezonyango, i-Huperzine A powder, iipilisi, ii-capsules, kunye neenaliti ze-freeze-dried powder zisetyenziswa kakhulu njengonyango oluncedisayo lokulahlekelwa yimemori, isifo se-Alzheimer's (AD), i-vascular dementia, kunye ne-myasthenia gravis.
I-COA
| Into | Inkcazo | Iindlela |
| Inkcazo | Umgubo ocolekileyo | I-Organoleptic |
| Umbala | Umgubo omhlophe | Imbonakalo |
| Uvavanyo(%) | I-NLT 99% | I-HPLC |
| Ilahleka xa yomiswa (%) | I-NMT 5% | 5g / 105℃ /iiyure ezi-4 |
| Ubungakanani be-mesh | I-95% idlula i-80 mesh | I-USP |
| IINTSIMBI EZINZIMA | ≤10.00mg/Kg | I-USP |
| I-Pb | ≤2.00 mg/Kg | I-AAS |
| Njengoko | ≤1.00 mg/Kg | I-AAS |
| I-Hg | ≤1.00 mg/Kg | I-AAS |
| I-CD | ≤1.00 mg/Kg | I-AAS |
| Umxholo wothuthu (%) | I-NMT 5% | 2g / 525℃ / iiyure ezi-3 |
| Iintsholongwane zizonke | ≤1000cfu/g | USP30 |
| Imvubelo kunye noMbungu | ≤100cfu/g | USP30 |
| I-Salmonella | Okungalunganga | USP30 |
| I-E. coli | Okungalunganga | USP30 |
| Ukuchongwa | I-HPLC/UV-VIS/GC | |
| Indawo yokugcina izinto | Kwindawo epholileyo neyomileyo, gcina kude nokukhanya okunamandla nobushushu. | |
| Ingxelo | Ixesha lokugcinwa: Iminyaka emibini xa igcinwe kakuhle. | |
Idosi kunye nokunikezelwa kweHuperzine A
I-Huperzine A yi-alkaloid entsha ekhutshwe kwisityalo iMelaleuca sohlobo lweMelaleuca. Inomsebenzi onamandla we-cholinomimetic kwaye ingumthinteli we-cholinesterase osebenza kakuhle kakhulu kwaye oguqulwayo. Ngokuthintela i-cholinesterase, ithintela ukonakala kwe-acetylcholine kwaye yonyusa umsebenzi wayo, nto leyo enokuphucula ukudluliselwa kwe-neurotransmitter. Iziphumo eziphambili kukuhlanza nokuqunjelwa.
Isetyenziswa ngokwezonyango ukunyanga isifo se-Alzheimer. Isifo se-Alzheimer sisifo esiwohlokayo kwinkqubo yemithambo-luvo esivame ukwenzeka kubantu abangaphezu kweminyaka engama-60 ubudala kwaye siqala ngendlela engaqondakaliyo. Sinokubonakala njengokuwohloka kwengqondo okuqhubekayo kunye notshintsho lobuntu. Akukho nyango luthile. Amayeza aphucula imetabolism yobuchopho kunye nokuphucula ukujikeleza kwegazi angasetyenziswa kwinqanaba lokuqala. I-Donepezil kunye ne-Shishanmaine A nazo zingasetyenziswa.
Ulawulo lwesayensi lwe-huperzine A
Amayeza omlomo
Iipilisi/iikhaphu zeHuperzine A: Umlinganiselo oqhelekileyo: 50 mcg (0.05 mg) ngepilisi nganye (ikhaphu).
• Ukuphazamiseka kwenkumbulo, isifo sika-Alzheimer: 0.1–0.2 mg (iipilisi ezi-2–4) kabini ngemini, zithathwa ngamanzi afudumeleyo emva kwesidlo sakusasa nesasemini. Ubude bonyango ziiveki ezi-4-6, kwaye unyango olu-1-2 lunokuqhubeka ngokusekwe ekusebenzeni kakuhle nasekunyamezelekeni.
• Abantu abadala abasempilweni abafuna ukuphucula ukufunda nokusebenza: Qala nge-50 mcg kusasa ungenanto esiswini. Emva kweentsuku ezi-3 ukuya kwezi-5, yongeza iye kwi-100 mcg kabini ngemini ngaphandle kokuba kukho ukungakhululeki okukhulu. Umthamo ophezulu wemihla ngemihla akufuneki udlule kwi-0.45 mg (iipilisi ezi-9).
• Ukuba kukho iimpawu zokukhuthazwa yi-cholinergic ezifana nokucaphuka, ukuhlanza, kunye norhudo, yehlisa umthamo okanye uyeke ukusebenzisa iyeza ngoko nangoko. Iimpawu zihlala ziphela ngokwazo kwiiyure ezingama-24.
Ukubumba ngenaliti
Umgubo owomileyo weHuperzine oqandisiweyo wokujova: 0.2 mg/ibhotile okanye 0.4 mg/ibhotile.
• Ukuphazamiseka kwenkumbulo: i-0.2 mg inyibilikiswe kwi-2 mL yamanzi acocekileyo ngokujova kwaye ijovwe nge-intramuscularly kanye ngemini kangangeeveki ezi-2-4, emva koko itshintshelwe ekugcinweni komlomo.
• I-Myasthenia gravis: 0.2-0.4 mg nge-intramuscularly kanye ngemini kangangeeveki ezi-4-6, okanye njengoko kuyalelwe ngugqirha.
• Inaliti ekhawulezileyo, i-Tmax malunga nemizuzu eli-10-30 kunye nokufumaneka kwayo ngaphakathi >95%. Nangona kunjalo, oku kufuneka kwenziwe phantsi kweliso lesibhedlele okanye ingcali yezempilo efanelekileyo ukuze kuthintelwe iimpembelelo ezimbi ezifana nentlungu yasekuhlaleni kunye nokudumba.
Isiphumo se-huperzine A powder ebuthongweni
Ngokubanzi: iidosi eziphantsi zomlomo (0.05–0.1 mg) aziphazamisi kakhulu ulwakhiwo lokulala; endaweni yoko, zinokuphucula ngokungathanga ngqo umgangatho wokulala ngokuphucula ukusebenza kwengqondo emini kunye nokunciphisa ixhala.
Iidosi eziphezulu okanye abantu abanomdla wokuziva bekhululekile: Emva kokuthatha idosi enye yomlomo engaphezulu kwe-0.3 mg, abanye abantu bafumana iimpawu ze-cholinergic hyperactivity ezifana nokungalali ixesha elide, ukurhawuzelela kwasekuseni okwandileyo.
Ndingawuthenga phi umgubo we-huperzine A?
Ukuba ufuna umgubo we-huperzine A okumgangatho ophezulu, ungaqhagamshelana neXi'an SOST Biotech Co., Ltd. ("SOST Biotech"), umthengisi weemveliso zezityalo oqeqeshiweyo. I-SOST Biotech isebenzisa indawo eqinisekisiweyo yi-cGMP kwaye inesiqinisekiso se-HACCP kunye ne-ISO22000. Ibonelela ngomgubo we-chrysin ococekileyo odlula i-98%. Ukupakisha okuqhelekileyo kubandakanya iingxowa zefoyile ye-aluminium eziyi-1 kg kunye needrama zekhadibhodi ezingama-25 kg. Sikwabonelela ngeenkonzo ze-OEM zeekhaphukhaphu, iitafile, kunye neziselo eziqinileyo.
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Amaphepha eDatha yeMveliso
| Into | Inkcazo | Iindlela |
| Inkcazo | Umgubo ocolekileyo | I-Organoleptic |
| Umbala | Umgubo omhlophe | Imbonakalo |
| Uvavanyo(%) | I-NLT 99% | I-HPLC |
| Ilahleka xa yomiswa (%) | I-NMT 5% | 5g / 105℃ /iiyure ezi-4 |
| Ubungakanani be-mesh | I-95% idlula i-80 mesh | I-USP |
| IINTSIMBI EZINZIMA | ≤10.00mg/Kg | I-USP |
| I-Pb | ≤2.00 mg/Kg | I-AAS |
| Njengoko | ≤1.00 mg/Kg | I-AAS |
| I-Hg | ≤1.00 mg/Kg | I-AAS |
| I-CD | ≤1.00 mg/Kg | I-AAS |
| Umxholo wothuthu (%) | I-NMT 5% | 2g / 525℃ / iiyure ezi-3 |
| Iintsholongwane zizonke | ≤1000cfu/g | USP30 |
| Imvubelo kunye noMbungu | ≤100cfu/g | USP30 |
| I-Salmonella | Okungalunganga | USP30 |
| I-E. coli | Okungalunganga | USP30 |
| Ukuchongwa | I-HPLC/UV-VIS/GC | |
| Indawo yokugcina izinto | Kwindawo epholileyo neyomileyo, gcina kude nokukhanya okunamandla nobushushu. | |
| Ingxelo | Ixesha lokugcinwa: Iminyaka emibini xa igcinwe kakuhle. | |
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