I-Spermidine Powder

Intshayelelo yeMveliso

• I-Spermidine, ekwabizwa ngokuba yi-spermidine trihydrochloride, yipolyamine. Isasazwa ngokubanzi kwizinto eziphilayo kwaye i-biosynthesized ukusuka kwi-purescine (butanediamine) kunye ne-adenosylmethionine. I-Spermidine inokuthintela i-neuronal synthase, ibophe kwaye iqhube i-DNA; ingasetyenziselwa ukuhlambulula i-DNA-binding proteins kunye nokuvuselela umsebenzi we-T4 polynucleotide kinase. NgoSeptemba 1, 2013, izazinzulu zaseJamani naseOstriya ziye zenza uphando kwaye zathi i-spermidine inokuthintela ukuqala kwesifo sika-Alzheimer.
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Inkqubo Ukuhamba komsebenzi

Umsebenzi weMveliso

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• I-Spermidine inokulibazisa ukuguga kweprotheyini. Ngenxa yokuba iiprotheyini zobunzima beemolekyuli ezahlukeneyo zinokudlala iindima ezahlukeneyo kwinkqubo ye-senescence, ezinye iiprotheyini ezinobunzima bemolekyuli zinokudlala indima ephambili ekulawuleni inkqubo ye-senescence yamagqabi. Emva kokuba ezi proteni ziqala ukuhla, i-senescence ayinakuphepheka, kwaye kunzima ukulawula ukuthotywa kwezi proteni. Inokulibazisa inkqubo yokwaluphala. Isizathu sokuba i-spermidine inokulibazisa ukuguga inokuba kukukhuthaza ukuhlanganiswa kwezi proteni okanye ukuthintela ukuthotywa kwazo.

Isicelo seMveliso

• I-Spermidine i-low molecular weight aliphatic carbide equkethe amaqela amathathu e-amine kwaye yenye ye-polyamines yendalo ekhoyo kuzo zonke izinto eziphilayo. Yimathiriyeli ekrwada ebalulekileyo yokwenziwa kweziyobisi kwaye isetyenziswa ngokubanzi kwi-synthesis ye-pharmaceutical intermediates.

  
  

  I-Spermidine ibandakanyeka kwiinkqubo ezininzi ze-biological kwizinto eziphilayo, ezifana nokulawula ukwanda kweeseli, i-cell senescence, ukuphuhliswa kwamalungu, ukukhuseleka, umhlaza kunye nezinye iinkqubo ze-physiological and pathological. Uphononongo lwakutsha nje lubonise ukuba i-spermidine idlala indima ebalulekileyo yolawulo kwiinkqubo ezifana ne-synaptic plasticity, uxinzelelo lwe-oxidative, kunye ne-autophagy kwinkqubo ye-nervous.
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