I-Ergothioneine Powder CAS 497-30-3

Impuphu ye-Ergothioneine iyi-amino acid yemvelo etholakala ezitshalweni futhi ingaqongelelwa ezilwaneni. Ucwaningo luye lwabonisa ukuthi inomphumela we-antioxidant. Ingasusa ngempumelelo i--OH, i-chelate divalent iron ion kanye ne-copper ion, futhi ivimbele i-H2O2 -OH ukuthi ikhiqizwe ngaphansi kwesenzo sama-iron ion noma ama-copper ion, okungavimbela futhi i-oxyhemoglobin encike kuma-ion ethusi. Ingavimbela futhi i-peroxidation ye-arachidonic acid ngemuva kokuthi i-myoglobin (noma i-hemoglobin) ixutshwe ne-H2O2. reaction. I-Ergothioneine ingaphinde ikhiphe i-hypochlorous acid ngamandla, ngaleyo ndlela ivimbele ukungasebenzi kwe-α1-antiprotease. Kodwa-ke, ayikwazi ukuvimbela ukusabela kwe-peroxidation kwezinhlayiya ze-lipid lapho kukhona ama-ion ensimbi. Izifundo zika-AKanmu D nabanye zibonise ukuthi ukuhlushwa okuthile kwe-ergothioneine emzimbeni kungasebenza njenge-antioxidant.

I-Ergothioneine iyisithako esinamandla sokukhipha i-hypochlorous acid (HOCl). Nakuba amakhemikhali amaningi angasabela nge-hypochlorous acid, ambalwa asabela ngokushesha njenge-ergothioneine. I-1-Antiprotease inhibitors (API), njenge-elastase, ibucayi kakhulu kwi-hypochlorous acid, futhi ukugcwala kwe-ergothioneine emzimbeni kungavikela ngempumelelo i-API ekungasebenzini okubangelwa yi-hypochlorous acid. Ama-neutrophils angumthombo oyinhloko we-hypochlorous acid emzimbeni, futhi omunye wemisebenzi ye-ergothioneine ukuvikela amangqamuzana abomvu egazi kuma-neutrophils avela ezindaweni ezivame ukusebenza noma ezivuvukalayo.

I-Peroxynitrite yakhiwe ngokwemvelo ngenxa yokusabela okulinganiselwe kokusabalala kwe-NO kanye ne-superoxide. Iyi-oxidant enamandla ehlobene ne-pathophysiology yokuvuvukala, njengokulimala kwe-ischemia-reperfusion, i-atherosclerosis, i-pneumonia ebukhali kanye ne-sepsis. I-Ergothioneine ingavimbela i-peroxynitrite anion-mediated amino acid oxidation, njenge-nitration ye-tyrosine, ngaleyo ndlela inikeze ithuba lokwelapha ukuvuvukala.

Kusukela ekutholakaleni kwe-ergothioneine, kuye kwenziwa imizamo eminingi yokucacisa imisebenzi yayo yomzimba, kodwa akekho oye wakwazi ukuchaza ngokuphelele imisebenzi yayo yomzimba. Ucwaningo lwe-Brummel.mc luthole ukuthi i-ergothioneine ingaba nemisebenzi elandelayo: ukuthutha ama-cation kanye nokuvuselela i-carbon dioxide carboxylation noma ukusabela kwe-decarboxylation; ukulawula imiphumela ye-thyroid kanye ne-anti-thyroid; ukulawula imiphumela ye-histamine noma ye-antihistamine; umsebenzi we-cholinergic noma imiphumela ye-anti-parasympathetic yomzimba; ingalawula ukusabela kwabanye abathwali be-acyl noma isebenze njengomthwali we-acid uqobo. U-Epand RM nabanye bafunde nomphumela we-ergothioneine kusifo sikashukela.

Inomsebenzi oqinile we-antioxidant: ukuxosha izinhlobo ze-oxygen ezisabelayo, ukugaya ama-ion ensimbi ahlukene, ukwenza ama-enzyme e-antioxidant asebenze, ukuvimbela i-superoxide dismutase, ukuvimbela ukusabela kwe-oxidation kwamaprotheni ahlukahlukene e-heme, njll. Ngenxa yalezi zakhiwo ze-ergothioneine, inohlu olubanzi lokusetshenziswa kanye namathuba emakethe emikhakheni yezokwelapha, ukudla neziphuzo, ukudla okusebenzayo, ukudla kwezilwane, izimonyo kanye ne-biotechnology.

Ucwaningo lukhombisile ukuthi i-ergothioneine ayikwazi ukwenziwa ezilwaneni, kodwa kuboniswe ngokusobala ukuthi i-histidine, i-sulfuratom, kanye namaqembu e-methyl e-methionine kungakhiwa (kufakwe) ezitshalweni nasezintweni ezincane. U-D. Yanasugondha kanye no-MD Appleman bafunde nge-catabolism ye-ergothioneine ezintweni ezincane. Bathole ukuthi i-ergothioneine ingaguqulwa ibe yi-trimethylamine kanye ne-thiol imidazole acrylic acid; UHeath [3] wondla amagundane esikhathi eside aqukethe i-[S] Ngemva kokudla i-ergothioneine, kwatholakala ukuthi i-ergothioneine enelebula le-[S] yayisatshalaliswa kumongo wethambo, amaseli egazi abomvu, isibindi, izinso nezinye izingxenye. UGeorge Wolf nabanye baqala ngokufaka i-[α-S]ergothioneine emagundwini, base befunda ukusatshalaliswa kwamandla anemisebe kanye nama-metabolites ayo. Kwafakazelwa ukuthi i-herzynine iyisandulela (isandulela) sokwenziwa kwe-ergothioneine.

Ngokuphathelene ne-ergothioneine, into enomsebenzi obalulekile nohlukile wezinto eziphilayo, izazi ezivela emazweni ahlukahlukene sezinesikhathi eside zenza ucwaningo ngokusetshenziswa kwayo. Nakuba isadinga ukujuliswa kakhulu, idlale indima ekhuthazayo kakhulu ekusetshenzisweni kwayo emikhakheni eyahlukene. I-Ergothioneine inokusetshenziswa okubanzi kanye namathuba emakethe emikhakheni yokufakelwa kwezitho zomzimba, ukulondolozwa kwamaseli, imithi, ukudla neziphuzo, ukudla okusebenzayo, ukudla kwezilwane, izimonyo kanye ne-biotechnology.

Impuphu ye-Ergothioneineiyi-antioxidant yemvelo evikela kakhulu, engenabo ubuthi engakhiqizi kalula emanzini, okuvumela ukuhlushwa kwayo kufinyelele kuma-molium kwezinye izicubu futhi kuvuselele uhlelo lokuvikela lwe-antioxidant lwemvelo lweseli. . Phakathi kwama-antioxidants amaningi, i-ergothioneine ihlukile kakhulu ngoba i-ergothioneine ingakhipha ama-ion ensimbi esindayo futhi ivikele amaseli abomvu egazi emzimbeni ekulimaleni kwama-free radical.

Inani kanye nobude bokulondolozwa kwezicubu ezikhona kudlala indima ebalulekile empumelelweni yokufakelwa kwezitho. I-antioxidant esetshenziswa kakhulu ekulondolozeni ukufakelwa kwezitho yi-glutathione. Uma ivezwa endaweni ezungezile, i-oxidized kalula. Ngisho nasezindaweni eziqandisiwe noma ezimanzi, amandla ayo okulwa ne-antioxidant ancishiswa kakhulu futhi inobuthi kumaseli. Iphinde ikhiqize ukuvuvukala futhi ibangele i-hydrolysis yamaprotheni ezicubu. I-Ergothioneine ifana ne-antioxidant ezinzile engxubeni yamanzi futhi ingaphinde ikhiphe ama-ion ensimbi esindayo. Emkhakheni wokuvikelwa kwezitho, ingasetshenziswa esikhundleni se-glutathione ukuze ivikele kangcono izitho ezitshaliwe.

I-Ultraviolet UVA elangeni ingangena esikhumbeni somuntu, ithinte ukukhula kwamangqamuzana e-epidermal, ibangele ukuthi amangqamuzana angaphezulu aguge futhi afe, ibangele ukuguga kwesikhumba ngaphambi kwesikhathi, kuyilapho i-ultraviolet UVB ingaholela kalula ekuveleni komdlavuza wesikhumba. I-Ergothioneine inganciphisa ukwakheka kwezinhlobo ze-oxygen ezisabelayo futhi ivikele amangqamuzana ekulimaleni kwemisebe. Ngakho-ke, i-ergothioneine ingangezwa kwezinye izimonyo njengesivikelo sesikhumba ukuthuthukisa imikhiqizo yokunakekelwa kwesikhumba yangaphandle kanye nezimonyo zokuzivikela.

Eminyakeni yamuva nje, izifundo zithole ukuthi i-ergothioneine idlala indima ebalulekile ekuvikelweni kwamehlo. Ngakho-ke, abacwaningi abaningi banethemba lokuthuthukisa umkhiqizo wamehlo ukuze kuthuthukiswe ukuthuthukiswa kokuhlinzwa kokwelashwa kwamehlo. Ukuhlinzwa kwamehlo ngokuvamile kwenziwa endaweni, futhi ukuncibilika kwamanzi kanye nokuqina kwe-ergothioneine kunikeza ithuba lokuhlinzwa okunjalo futhi kunenani elikhulu lokusetshenziswa.

I-Ergothioneine ingasetshenziswa emikhakheni eminingi ngenxa yezakhiwo zayo ezinhle kakhulu. Isibonelo, isetshenziswa emikhakheni yezokwelapha, ukudla, imikhiqizo yezempilo, izimonyo, njll. Emkhakheni wezokwelapha, ingasetshenziswa ukwelapha ukuvuvukala, njll., futhi ingenziwa amaphilisi, ama-capsule, amalungiselelo omlomo, njll.; emkhakheni wemikhiqizo yezempilo, ingavimbela ukwenzeka komdlavuza, njll., futhi ingenziwa ukudla okusebenzayo, iziphuzo ezisebenzayo neminye imikhiqizo. Emkhakheni wezimonyo, ingasetshenziswa ukwelapha ukuvuvukala, njll. Isetshenziselwa ukulwa nokuguga futhi ingenziwa ibe yi-sunscreen neminye imikhiqizo.

Njengoba ulwazi lwabantu ngokunakekelwa kwempilo lukhula, izakhiwo ezinhle kakhulu ze-ergothioneine njenge-antioxidant yemvelo zizoqashelwa futhi zisetshenziswe kancane kancane.

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