I-Adenosine 58-61-7

I-Adenosine 58-16-7 iyi-nucleoside endogenous kuwo wonke amaseli omuntu. I-Adenosine ingangena ngqo kwi-myocardium futhi i-phosphorylated ukuze ikhiqize i-adenosine, ehlanganyela ekusetshenzisweni kwamandla e-myocardial, kanye nokwanda kwemithambo yegazi yenhliziyo kanye nokwanda kokugeleza kwegazi. I-Adenosine inemiphumela yemvelo ohlelweni lwenhliziyo nezinye izinhlelo eziningi nezicubu emzimbeni. I-Adenosine iyi-intermediate ebalulekile esetshenziswa ekwakhiweni kwe-adenosine triphosphate (ATP), i-adenine, i-adenosine, kanye ne-adenosine arabine.

Impuphu ye-Adenosine iyisithako esisebenzayo esine-nucleoside ne-purine njengesakhiwo esiyisisekelo. I-Adenosine iyi-nucleoside eyakhiwe yi-adenine ehlanganisa i-D-ribose ngesibopho se-β-glucoside. Itholakala kabanzi kuzo zonke izinhlobo zamaseli futhi iyi-nucleoside yamahhala nehlanganisiwe kuma-nucleic acid. Ama-ester e-phosphate e-Adenosine afana ne-ATP ayizithwali zamandla ezibalulekile ekuphenduleni kwamakhemikhali. I-Adenosine iyi-nucleotide yemvelo, umkhiqizo ophakathi wokusebenza komzimba, futhi ingenye yezingxenye ezibalulekile ezisebenzayo emzimbeni. Isebenza ngokusebenzisa ama-receptor e-adenosine (ama-receptor e-A). Ku-atria, i-node ye-sinoatrial, kanye ne-node ye-atV, i-adenosine isebenzisa iziteshi ze-potassium ezihlanganiswe ne-G protein ngokubopha kwi-receptor ye-A, yandise ukuphuma kwe-K+, futhi inciphise i-membrane hyperpolarization kanye ne-automaticity. Ingakhulisa kakhulu izinga le-cGMP, yandise i-ERP ye-node ye-atrioventricular futhi yehlise ijubane lokuqhuba, ivimbele i-depolarization yokuqala neyephuzile ebangelwa yi-sympathetic nerve noma i-isoproterenol, futhi idlale indima yokulwa ne-arrhythmic. Lo mkhiqizo awuzange uhlukaniswe ngemithi yesigaba I ~ Ⅳ yokulwa nokushaya kwenhliziyo. I-Adenosine powder iyi-neuromodulator evimbelayo ohlelweni lwezinzwa oluphakathi enikeza isignali yokulinganisela phakathi kokugcinwa kwamandla kobuchopho nezidingo zamandla. Ngaphansi kwezimo ezijwayelekile, amazinga e-adenosine angaphandle agcinwa phakathi kuka-40 no-400 nmol. Uma kwenzeka i-ischemia kanye ne-hypoxia, kokubili i-glucose kanye ne-glycogen kusheshisa ukubola ukuze kukhiqizwe i-ATP ukuze kuhlangatshezwane nesidingo samandla, bese i-ATP ibola, okuholela ekukhuleni okukhulu kwezinga le-adenosine esitokisini kanye nokukhululwa kwayo ngaphandle kweseli ukuze idlale indima yayo yokulawula. Esigabeni sokululama kwe-hypoxia, i-adenosine engokwemvelo, njengesandulela sokwenziwa kwe-ATP, ingavuselelwa ibe yi-ATP ngaphansi kwe-catalysis ye-adenosine kinase (AK) ukuze kwandiswe isikhathi sokusinda kwamaseli. I-Adenosine yandisa imithambo yenhliziyo futhi inciphise ukugoba kwe-myocardial. Isebenza ngokwezokwelapha ekwelapheni i-angina pectoris, umfutho wegazi ophakeme, izifo ze-cerebrovascular, i-stroke sequelae, i-progressive muscular atrophy nokunye. Umjovo womjovo we-intravenous wasetshenziswa ukwelapha i-supraventricular tachycardia kanye ne-201Tl myocardial imaging. ngenhla.

1. I-Adenosine ingasetshenziswa ukwelapha i-angina pectoris, i-myocardial infarction, ukungasebenzi kahle kwemithambo yenhliziyo, i-arteriosclerosis, umfutho wegazi ophakeme, izinkinga ze-cerebrovascular, imiphumela yesifo sohlangothi, ukuwohloka kwemisipha okuqhubekayo, njll.

Uma ufuna ukuthenga i-Adenosine 58-61-7 powder yezinga lobuhle, ungaxhumana ne-SOST Biotech. Singochwepheshe ekuhlinzekeni ngezinto zokusetshenziswa zobuhle futhi singenza ngezifiso imikhiqizo ngokwendlela oyikhethile.