I-Adenosine 58-61-7

I-Adenosine iyi-nucleoside engapheli kuwo wonke amangqamuzana omuntu. I-Adenosine ingangena ngqo ku-myocardium kanye ne-phosphorylated ukuze ikhiqize i-adenosine, ebamba iqhaza kumetabolism yamandla e-myocardial, kanye nokwandiswa kwemithambo yegazi ye-coronary kanye nokwanda kokugeleza kwegazi. I-Adenosine inemiphumela yokuphila ohlelweni lwenhliziyo nezinye izinhlelo eziningi nezicubu emzimbeni. I-Adenosine iyisiphakathi esibalulekile esisetshenziswa ekuhlanganiseni i-adenosine triphosphate (ATP), i-adenine, i-adenosine, ne-adenosine arabine.

I-Adenosine iyisithako esisebenzayo esine-nucleoside ne-purine njengesakhiwo esiyisisekelo. I-Adenosine iyinucleoside eyakhiwe i-adenine ehlanganisa i-D-ribose ngebhondi ye-β-glucoside. Itholakala kabanzi kuzo zonke izinhlobo zamaseli futhi ikhululekile futhi ihlanganisiwe i-nucleoside kuma-nucleic acid. I-Adenosine phosphate esters efana ne-ATP iyizithwali zamandla ezibalulekile ekuphenduleni kwamakhemikhali ezinto eziphilayo. I-Adenosine iyi-nucleotide yemvelo, umkhiqizo ophakathi we-metabolism yomzimba, futhi enye yezingxenye ezibalulekile ezisebenzayo emzimbeni. Isebenza ngokuvula ama-adenosine receptors (A receptors). Ku-atria, node ye-sinoatrial, ne-atV node, i-adenosine yenza kusebenze iziteshi ze-potassium ezihlanganiswe namaprotheni e-G ngokubophezela ku-A receptor, ikhulise ukuphuma kwe-K+, futhi yehlise i-hyperpolarization ye-membrane kanye nokuzenzakalela. Ingase futhi ikhulise ngokuphawulekayo izinga le-cGMP, inwebe i-ERP ye-atrioventricular node futhi ibambezele ukuqhutshwa, ivimbele ukuchithwa kwe-depolarization kwasekuqaleni nakwephuzile okubangelwa inzwa enozwela noma i-isoproterenol, futhi idlale indima ye-antiarrhythmic. Lo mkhiqizo awuzange ubekwe esigabeni I ~ Ⅳ izidakamizwa ezilwa nokuvuvukala. I-Adenosine iyi-neuromodulator evimbelayo ohlelweni lwezinzwa olumaphakathi olunikeza isignali yokulinganisela phakathi kokugcinwa kwamandla obuchopho nezidingo zamandla. Ngaphansi kwezimo ezijwayelekile, ukugxila kwe-extracellular adenosine kugcinwa phakathi kuka-40 no-400 nmol. Uma kwenzeka i-ischemia ne-hypoxia, kokubili i-glucose ne-glycogen kusheshisa ukubola ukuze kukhiqizwe i-ATP ukuze ihlangabezane nesidingo samandla, bese i-ATP iyancipha, okuholela ekwenyukeni okukhulu kwezinga le-adenosine engqamuzaneni kanye nokukhululwa kwayo ngaphandle kwengqamuzana ukuze idlale indima yayo yokulawula. Esigabeni sokululama se-hypoxia, i-adenosine engapheli, njengesandulela se-ATP synthesis, ingavuselelwa ibe yi-ATP ngaphansi kwe-catalysis ye-adenosine kinase (AK) ukuze kunwetshwe isikhathi sokusinda samaseli. I-Adenosine ivula imithambo yenhliziyo futhi inciphise ukufinyela kwe-myocardial. Isebenza ngokomtholampilo ekwelapheni i-angina pectoris, umfutho wegazi ophakeme, iziyaluyalu ze-cerebrovascular, i-stroke sequelae, i-progressive muscular atrophy nokunye. Umjovo we-intravenous wawusetshenziselwa ukwelapha i-supraventricular tachycardia kanye ne-201Tl ye-myocardial imaging. ngenhla

1. I-Adenosine ingasetshenziswa ekwelapheni i-angina pectoris, i-myocardial infarction, i-coronary artery insufficiency, i-arteriosclerosis, i-hypertension ebalulekile, ukuphazamiseka kwe-cerebrovascular, sequelae of stroke, i-progressive muscle atrophy, njll.