I-Fisetin Powder Bulk

Fisetin powder ngobuningi i-flavonol yemvelo eyaqala ukuhlukaniswa nezitshalo zomndeni wakwa-Anacardiaceae, yingakho igama layo. Uhlaka lwamathambo ayo amangqamuzana ama-polyphenols, anefomula yekhemikhali engu-C₁₅H₁₀O₆, CAS No. 528-48-3, futhi iyimpushana ephuzi ephuzi ukuya kokumhlophe. Ayincibiliki emanzini, kodwa incibilika kalula kuzincibilikisi ze-polar njenge-acetone, i-ethanol, ne-dimethyl sulfoxide. Emvelweni, ukudla okufana nama-strawberry, ama-apula, u-anyanisi, ukhukhamba, nezikhumba zamagilebhisi konke kuqukethe inani elincane le-Fisetin, kodwa inani eliphelele liphansi kakhulu - Izazi zaseJapane zithole ukuthi isilinganiso sokudla kwansuku zonke kumuntu ngamunye silinganiselwa ku-0.4 mg kuphela. Uma ufuna ukudlala indima ecacile ocwaningweni lwesayensi noma ekudleni okusebenzayo, ngokuvamile udinga i-"Fisetin powder" impahla eluhlaza enobumsulwa obungu-≥98%, etholakala ngezinqubo ezinjengokukhishwa okungahluziwe kwe-Cotinus coggygria noma ama-strawberry, ukucwengisiswa kwe-chromatography, kanye ne-recrystallization, bese ifaneleka nge-HPLC indlela esezingeni eliphansi ngaphambi kokuthi ingene ezindleleni ezijwayelekile zangaphandle.

Esinye sezici ezivamile ze-pathological zezifo ze-neurodeergenerative ezifana nesifo i-Alzheimer's (AD) nesifo sika-Parkinson (PD) i-neuroinflammation engapheli. I-Fisetin inciphisa ukukhululwa kwe-proinflammatory cytokines TNF-α, IL-1β, ne-IL-6 ngokuvimbela indlela yokubonisa i-NF-κB, ngaleyo ndlela inciphisa "ukushaya kwesibili" okubangelwa ukusebenza ngokweqile kwe-microglia.

Ukuhlolwa kwezilwane kubonise ukuthi i-Fisetin ingakwazi ukwenza kusebenze indlela ye-ERK/CREB, ikhulise ukuvezwa kwamaprotheni e-synaptic synapsin I kanye ne-PSD95, futhi ithuthukise amandla esikhathi eside (LTP), okubonakala ekugcineni njengokuthuthuka kwekhono lokufunda nokufunda nokuhlanganisa inkumbulo.

Kumagundane emodeli ye-AD transgenic, ukuphathwa okuqhubekayo kwe-Fisetin powder 25 mg/kg izinyanga ze-3 kunganciphisa kakhulu indawo ye-Aβ42 plaques ku-hippocampus futhi kubuyisele emuva ukulahlekelwa kwememori.

I-Fisetin ikhonjiswe ukuthi ilawula isisho se-SIRT1, ithuthukise ukusebenza kwe-mitochondrial, futhi ibambezele ukuguga kwamaseli. Le nqubo ayihlobene kuphela ne-neuroprotection, kodwa futhi ibhekwa njengento entsha ehlosiwe yocwaningo lokulwa nokuguga.

Idosi ephansi (≤25 mg/ingxenye) ingasetshenziswa njengesithako sefomula "yokusekela inkumbulo" futhi yengezwe kumabha wamandla kanye neziphuzo ezisebenzayo esezilungele ukuphuzwa.

Ngokusebenzisa izakhiwo zayo eziqinile zokulwa ne-antioxidant, i-fisetin powder ingafakwa kumakhilimu kanye ne-essences ukulwa nokucindezeleka kwe-oxidative yesikhumba nokunciphisa ukuthungwa kwezithombe.

I-CMS121 ephuma kokunye ene-fisetin njengomgogodla womzali yethulwe e-United States ukuze zelashwe i-AD ezivivinyweni zeSigaba I futhi ingase ingene emakethe yezidakamizwa enikezwa ngudokotela esikhathini esizayo.

I-high-purity fisetin powder isetshenziswa kakhulu kumamodeli wokucindezeleka kwe-cell oxidative kanye nokuhlolwa kokuziphatha kwezilwane ukuze kufundwe izindlela zesifo i-Alzheimer's, isifo sika-Parkinson, kanye ne-amyotrophic lateral sclerosis (ALS).

Ucwaningo lokuqala luye lwathola ukuthi i-fisetin powder ingakwazi ukulwa ne-encephalopathy ebuhlungu engapheli (CTE) ebangelwa ukuphikisana okuphindaphindiwe ngokuvimbela i-neuroinflammation nokukhuthaza izici ze-neurotrophic.