Izithako Zemithi Ezisebenzayo
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Iyini i-Fisetin Powder Bulk?
Inqwaba ye-Fisetin powder iyi-flavonol yemvelo eyaqala ukuhlukaniswa ezitshalweni zomndeni wakwa-Anacardiaceae, yingakho ibizwa kanjalo. Uhlaka lwayo lwama-molecule lungolwama-polyphenols, olunefomula yamakhemikhali ye-C₁₅H₁₀O₆, i-CAS No. 528-48-3, futhi luyimpuphu ekristalu ephuzi ngokuphaphathekile kuya kokumhlophe. Ayincibiliki emanzini, kodwa incibilika kalula ezinyibilikisini ze-polar ezifana ne-acetone, i-ethanol, ne-dimethyl sulfoxide. Ngokwemvelo, ukudla okufana nama-strawberry, ama-apula, u-anyanisi, ukhukhamba, kanye nezikhumba zamagilebhisi konke kuqukethe inani elincane le-Fisetin, kodwa inani eliphelele liphansi kakhulu - izazi zaseJapan zibale ukuthi ukudla okujwayelekile kwansuku zonke ngomuntu ngamunye kungama-0.4 mg kuphela. Uma ufuna ukudlala indima ecacile ocwaningweni lwesayensi noma ekudleni okusebenzayo, ngokuvamile udinga izinto zokusetshenziswa "ze-Fisetin powder" ezihlanzekile ezingama-≥98%, ezitholakala ngezinqubo ezifana nokukhishwa kwe-Cotinus coggygria noma i-strawberry, ukuhluzwa kwe-chromatography, kanye nokuvuselelwa kabusha, bese kuqinisekiswa indlela ejwayelekile yangaphandle ye-HPLC ngaphambi kokuthi ingene ezicelweni ezingezansi.
I-COA ye-Fisetin Powder ngobuningi
| Ukuhlaziywa | Incazelo | Indlela Yokuhlola |
| Ukubukeka | Impuphu Ephuzi | Okubonakalayo |
| Iphunga | Isici | I-Organoleptic |
| Ukuhlonza | Vumelana nesampula yokubhekisela | I-Organoleptic |
| Usayizi We-Mesh | I-100% idlula i-mesh engu-80 | Isikrini se-80mesh |
| Okuqukethwe komswakama | ≤ 1.0% | GB5009.3-2016 |
| Izinsimbi Ezisindayo | ≤ 10 ppm | I-GB 5009.3 |
| I-Arsenic (Njengoba) | ≤ 1.5 ppm | I-GB 5009.4 |
| I-Lead (Pb) | ≤ 2 ppm | I-GB 5009.11 |
| I-Cadmium (i-Cd) | ≤1ppm | I-GB 5009.12 |
| I-Mercury (Hg) | ≤1ppm | I-GB 5009.17 |
| Inani Eliphelele Lepuleti | ≤10000 cfu/g | I-GB 5009.15 |
| Imvubelo Nokukhunta | ≤100 cfu/g | I-GB 5009.3 |
| I-Escherichia Coli | I-GB 5009.4 | |
| I-Salmonella/25g | Akukho | I-GB 5009.11 |
| Isakhi esisebenzayo | I-Fisetin≥98% | I-HPLC |
Iyini imiphumela ye-Fisetin powder ebuchosheni?
Ilwa nokuvuvukala kanye ne-immunomodulatory
Esinye sezici ezivamile zezifo eziwohlokayo zemizwa njengesifo i-Alzheimer's (AD) kanye nesifo sikaParkinson (PD) ukuvuvukala kwemizwa okungapheli. I-Fisetin inciphisa ukukhishwa kwama-cytokines abangela ukuvuvukala i-TNF-α, i-IL-1β, kanye ne-IL-6 ngokuvimbela indlela yokubonisana ye-NF-κB, ngaleyo ndlela inciphise "ukushaya kwesibili" okubangelwa ukusebenza ngokweqile kwe-microglia.
Khuthaza i-neuroplasticity
Ukuhlolwa kwezilwane kubonise ukuthi i-Fisetin ingasebenzisa indlela ye-ERK/CREB, yandise ukubonakaliswa kwamaprotheni e-synaptic i-synapsin I kanye ne-PSD95, futhi ithuthukise amandla esikhathi eside (LTP), okugcina kubonakala njengokuthuthuka kwekhono lokufunda nokuhlanganisa inkumbulo.
Nciphisa ukufakwa kwe-β-amyloid
Kumagundane e-AD transgenic model, ukuphathwa okuqhubekayo kwe-Fisetin powder engu-25 mg/kg izinyanga ezi-3 kunganciphisa kakhulu indawo yama-plaque e-Aβ42 ku-hippocampus kanye nokulahlekelwa yinkumbulo okubuyiselwe emuva.
Yenza kusebenze iphrotheni ye-SIRT1 yokuphila isikhathi eside
I-Fisetin iboniswe ukuthi ikhulisa ukubonakaliswa kwe-SIRT1, ithuthukisa ukusebenza kwe-mitochondrial, futhi ilibazise ukuguga kwamaseli. Le ndlela ayihlobene nje kuphela nokuvikela izinzwa, kodwa futhi ibhekwa njengento entsha yocwaningo lokulwa nokuguga.
Kukuziphi izinkambu lapho i-fisetin ingasetshenziswa khona?
Ukudla okusebenzayo/ukudla okukhethekile kwezokwelapha
Umthamo ophansi (≤25 mg/ingxenye) ungasetshenziswa njengesithako sefomula "sokusekela inkumbulo" futhi ungezwe kuma-energy bar kanye neziphuzo ezisebenzayo ezilungele ukuphuza.
Izimonyo ezilwa nokuguga
Isebenzisa izakhiwo zayo ezinamandla zokulwa ne-antioxidant, i-fisetin powder ingafakwa kuma-creams kanye nama-essence ukuze kulwiwe nokucindezeleka kwe-oxidative kwesikhumba futhi kuncishiswe ukuguga kwesithombe.
Amakhemikhali amasha angase abe yimithi
I-derivative CMS121 ene-fisetin njengomgogodla oyinhloko yethulwe e-United States ukuze kwelashwe i-AD ezivivinyweni zeSigaba I futhi ingangena emakethe yemithi kadokotela esikhathini esizayo.
Ama-reagent ocwaningo lwesayensi yezinzwa
Impuphu ye-fisetin emsulwa kakhulu isetshenziswa kabanzi kumamodeli okucindezeleka kwe-oxidative yamaseli kanye nokuhlolwa kokuziphatha kwezilwane ukuze kufundwe izindlela zesifo se-Alzheimer's, isifo sikaParkinson, kanye ne-amyotrophic lateral sclerosis (ALS).
Ezokwelapha Ezemidlalo
Izifundo zokuqala zithole ukuthi i-fisetin powder ingalwa nesifo esingapheli se-encephalopathy (CTE) esibangelwa ukuxhuzula okuphindaphindiwe ngokuvimbela ukuvuvukala kwe-neuroinflammation nokukhuthaza izici ze-neurotrophic.
Ngingayithenga kuphi i-fisetin powder bulk? Xhumana ne-SOST
Uma udinga izinto zokusetshenziswa ze-fisetin powder bulk ezihlangabezana nezindinganiso ze-USP/EP futhi ezinokuqukethwe okungu-≥98%, noma ufuna ukwenza ukukhiqizwa kwelebula yangasese ye-OEM/ODM, ungaxhumana ngqo ne-SOST, umhlinzeki ochwepheshe wezitshalo ezikhishwe. I-SOST ineminyaka engaphezu kwengu-10 yesipiliyoni ekukhiqizweni kwama-monomers e-flavonoid, futhi ingahlinzeka ngokuhlinzekwa okuzinzile kusuka kumagremu kuya kumathani, futhi isekela isethi ephelele yamadokhumenti okuhambisana nemithetho njenge-COA, i-MSDS, kanye nemibiko yokuhlolwa yomuntu wesithathu.
Xhumana nathi Amashidi Edatha Yomkhiqizo
| Ukuhlaziywa | Incazelo | Indlela Yokuhlola |
| Ukubukeka | Impuphu Ephuzi | Okubonakalayo |
| Iphunga | Isici | I-Organoleptic |
| Ukuhlonza | Vumelana nesampula yokubhekisela | I-Organoleptic |
| Usayizi We-Mesh | I-100% idlula i-mesh engu-80 | Isikrini se-80mesh |
| Okuqukethwe komswakama | ≤ 1.0% | GB5009.3-2016 |
| Izinsimbi Ezisindayo | ≤ 10 ppm | I-GB 5009.3 |
| I-Arsenic (Njengoba) | ≤ 1.5 ppm | I-GB 5009.4 |
| I-Lead (Pb) | ≤ 2 ppm | I-GB 5009.11 |
| I-Cadmium (i-Cd) | ≤1ppm | I-GB 5009.12 |
| I-Mercury (Hg) | ≤1ppm | I-GB 5009.17 |
| Inani Eliphelele Lepuleti | ≤10000 cfu/g | I-GB 5009.15 |
| Imvubelo Nokukhunta | ≤100 cfu/g | I-GB 5009.3 |
| I-Escherichia Coli | I-GB 5009.4 | |
| I-Salmonella/25g | Akukho | I-GB 5009.11 |
| Isakhi esisebenzayo | I-Fisetin≥98% | I-HPLC |
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