Impuphu ye-Spermidine

Isingeniso Somkhiqizo

• I-Spermidine, eyaziwa nangokuthi i-spermidine trihydrochloride, iyi-polyamine. Isatshalaliswa kabanzi ezintweni eziphilayo futhi yenziwe nge-biosynthesized kusuka ku-putrescine (butanediamine) kanye ne-adenosylmethionine. I-Spermidine ingavimbela i-neuronal synthase, ibophe futhi isheshise i-DNA; ingasetshenziswa futhi ukuhlanza amaprotheni ahlanganisa i-DNA futhi ivuselele umsebenzi we-T4 polynucleotide kinase. NgoSepthemba 1, 2013, ososayensi baseJalimane nase-Austria benza ucwaningo ngokubambisana futhi bathi i-spermidine ingavimbela ukuqala kwesifo i-Alzheimer's.
• 

Ukugeleza Komsebenzi Wenqubo

Umsebenzi Womkhiqizo

• 
• I-Spermidine ingalibazisa ukuguga kwamaprotheni. Ngenxa yokuthi amaprotheni anesisindo sama-molecule ahlukene angadlala indima ehlukene enkambisweni yokuguga, amanye amaprotheni amakhulu anesisindo sama-molecule angadlala indima ebalulekile ekulawuleni inqubo yokuguga kwamaqabunga. Uma lawa maprotheni eqala ukonakala, ukuguga akunakugwenywa, futhi kunzima ukulawula ukonakala kwalawa maprotheni. Kungalibazisa inqubo yokuguga. Isizathu sokuthi i-spermidine ingalibazisa ukuguga kungaba ukukhuthaza ukwakheka kwalawa maprotheni noma ukuvimbela ukonakala kwawo.

Isicelo Somkhiqizo

• I-Spermidine iyi-carbide ye-aliphatic enesisindo esincane sama-molecule equkethe amaqembu amathathu e-amine futhi ingenye yama-polyamine emvelo akhona kuzo zonke izinto eziphilayo. Iyinto eluhlaza ebalulekile yokwenziwa kwemithi futhi isetshenziswa kabanzi ekuhlanganisweni kwezidakamizwa eziphakathi.

  
  

  I-Spermidine ihilelekile ezinqubweni eziningi zezinto eziphilayo, njengokulawula ukwanda kwamaseli, ukuguga kwamaseli, ukuthuthukiswa kwezitho zomzimba, ukuzivikela komzimba, umdlavuza kanye nezinye izinqubo zomzimba nezezifo. Izifundo zakamuva zibonise ukuthi i-spermidine idlala indima ebalulekile ekulawuleni izinqubo ezifana ne-synaptic plasticity, ukucindezeleka kwe-oxidative, kanye ne-autophagy ohlelweni lwezinzwa.
•