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I-Shikonin (i-shikonin, i-shikonin, i-shikonin) iklasi lemikhiqizo yemvelo enesakhiwo se-naphthoquinone esikhishwe empandeni ye-Lithospermum officinale, ene-anti-inflammatory, antioxidant, anti-tumor, nemiphumela yokuphulukisa isilonda. Eminyakeni yamuva nje, imiphumela yokulwa ne-tumor ye-shikonin kanye nokuphuma kwayo kuye kwafundwa kabanzi. Ucwaningo oluningana lwe-in vitro kanye ne-in vivo lubonise ukuthi i-shikonin kanye nokuphuma kwayo kungavimbela ngempumelelo ukwenzeka nokuthuthuka kwezifo ezithinta izifo zabesifazane njengomdlavuza webele kanye nomdlavuza womlomo wesibeletho. I-Shikonin inomphumela onamandla wokulwa nomdlavuza ezinhlotsheni ezihlukahlukene zomdlavuza ngokuvimbela ukwanda kwamangqamuzana nokufuduka, ibangele i-apoptosis yamaseli, i-autophagy kanye ne-necroptosis. I-Shikonin ingase futhi iqalise ukukhiqizwa kwezinhlobo ze-oxygen esebenzayo (i-ROS), ivimbele ukukhululwa kwama-exosomes, futhi isebenze i-anti-tumor immunity ngokusebenzisa izindlela ezihlukahlukene zamangqamuzana.